1093759-67-1

Basic information

• Product Name: tert-Butyl 4-acetaMidopiperidin-1-carboxylate
• Synonyms: tert-Butyl 4-acetaMidopiperidin-1-carboxylate;tert-Butyl 4-acetaMidopiperidine-1-carboxylate;4-Acetylamino-1-Boc-piperidine
• CAS NO: 1093759-67-1
• Molecular Formula: C12H22N2O3
• Molecular Weight: 242.31468
• Mol File: 1093759-67-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 4-acetaMidopiperidin-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-acetaMidopiperidin-1-carboxylate(1093759-67-1)
• EPA Substance Registry System: tert-Butyl 4-acetaMidopiperidin-1-carboxylate(1093759-67-1)

Safety Data

• Statements: 20/21/22
• Safety Statements: 23-24/25
• Hazardous Substances Data: 1093759-67-1(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 4-acetamidopiperidin-1-carboxylate is a chemical compound often used in scientific research, particularly for synthesis and chemical manipulation. It has a molecular formula of C14H26N2O3 and is categorized as a piperidine, a type of organic compound with a saturated cyclic structure. It is commonly used as a reagent in the creation of other compounds due to its stable properties. This chemical is characterized by its reactivity and is typically handled and stored under controlled conditions in a laboratory to prevent unwanted reactions or degradation. It plays an important role in the field of pharmaceuticals and experimental science due to its versatility and robustness.

Upstream product

• 87120-72-7 1-(tert-butoxycarbonyl)-4-aminopiperidine 
• 75-36-5 acetyl chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 873088-90-5 1,1-dimethylethyl 4-[bis(phenylmethyl)amino]-1-piperidinecarboxylate 
• 206989-61-9 4-acetyl-1-(t-butoxycarbonyl)piperidine 

Downstream Products

• 5810-56-0 4-(acetylamino)piperidine 
• 58083-34-4 4-acetylaminopiperidine hydrochloride 

Relevant articles and documents

Mild, calcium catalysed Beckmann rearrangements

A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.

Discovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl] piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An allosteric muscarinic M 1 receptor agonist with unprecedented selectivity and procognitive potential

The discovery and Structure-activity relationship (SAR) of a series of allosteric muscarinic M1 receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as an agonist at the muscarinic M1 receptor across a panel of muscarinic receptor subtypes. Furthermore, 17 displayed a high degree of selectivity when tested in a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, and 17 showed an acceptable pharmacokinetic profile and sufficient brain exposure in rodents in order to characterize the compound in vivo. Hence, in a rodent model of learning and memory, 17 reversed delay-induced natural forgetting, suggesting a procognitive potential of 17.