109388-01-4

Upstream product

• 503-64-0 (Z)-but-2-enoic acid 
• 1624-46-0 (E)-1,N-bis(4-methoxyphenyl)methanimine 
• 625-38-7 but-3-enoic acid 
• 1749-08-2 N-(4-methoxy benzylidene)-4-methoxyaniline 
• 1117-71-1 methyl-4-bromo-2-butenoate 
• 625-35-4 trans-chrotonyl chloride 

Downstream Products

• 109388-09-2 3-Acetyl-1,4-bis-(4-methoxy-phenyl)-azetidin-2-one 
• 109388-08-1 [1,2-Bis-(4-methoxy-phenyl)-4-oxo-azetidin-3-yl]-acetaldehyde 

Relevant academic research and scientific papers

DMF-dimethyl sulfate as a new reagent for the synthesis of β-lactams

A number of 2-azetidinones were synthesized in good to excellent yields by a novel reaction between Schiff bases, substituted acetic acids and alkoxymethylene-N,N-dimethyliminium salts, the adduct formed from DMF and O-alkylating agents. The advantages of

Carbocation catalyzed carboxylic acid activation in Staudinger reaction for stereoselective synthesis of β-lactams

A novel strategy to synthesize stereoselective β-lactams has been disclosed via cyclopropenium-ion-catalyzed reaction of substituted acetic acids with aldimines under mild conditions. Products are formed in high yields (86–95%) and good diastereoselectivi

Stereoselective synthesis, reactions and antimicrobial activity of 3-vinyl-2-azetidinones

Stereocontrolled synthesis of 3-vinyl-2-azetidinones has been achieved by the condensation of imines and conjugated acids using phosphorus oxychloride. Transformation of these compounds to other useful intermediates has also been accomplished. Some of the

The synthesis of β-lactams via a one-pot Reformatsky reaction of imines promoted by Zn/Cp2TiCl2 (cat.)

In the presence of Zn/Cp2TiCl2 (cat.) α-bromoacetates, γ-bromocrotonates or α-bromomethylacrylates react with imines in one-pot to form β-lactams, 3-vinyl-β-lactams or α-methylene-γ-lactams, respectively, at room temperature without

A NOVEL CHEMICAL TRANSFORMATION OF 3-VINYL-4-SUBSTITUTED-2-AZETIDINONES

Transformation of α-vinyl-β-lactams involving an anti-Markovnikov addition reaction is described.The action of PdCl2-CuCl-O2 on the vinyl group leads to terminal aldehydes instead of the expected methyl ketones.The intermediate prepa