360048-15-3

Upstream product

• 288-88-0 1,2,4-Triazole 
• 75-77-4 chloro-trimethyl-silane 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 117032-49-2 4-(1,2,4-triazol-1-yl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-trimethylsilyl thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 109389-25-5 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methyl-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one 
• 50-89-5 thymidine 

Downstream Products

• 101712-10-1 1-(2'-deoxy-5'-O-dimethoxytrityl-β-D-ribofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2-pyrimidone 3'-(N,N-diisopropylamido)-β-cyanoethylphosphite 
• 937376-82-4 4-(2-cyanoethyl)seleno-5'-O-(4,4'-dimethoxytriphenylmethyl)thymidine 

Relevant academic research and scientific papers

Nucleobase Modifiers Identify TET Enzymes as Bifunctional DNA Dioxygenases Capable of Direct N-Demethylation

TET family enzymes are known for oxidation of the 5-methyl substituent on 5-methylcytosine (5mC) in DNA. 5mC oxidation generates the stable base 5-hydroxymethylcytosine (5hmC), starting an indirect, multi-step process that ends with reversion of 5mC to un

4-SE-THYMIDINE DERIVATIVES, 4-SE-URIDINE DERIVATIVES, DI (2-CYANOETHYL) DISELENIDE, AND METHODS

A compound having the formula (I): wherein R1 is H, HO, acyl-O, TOM-O, ACE-O, alkyl-O, orthoester, TBDMS-O, HSe, diselenide, or alkyl-Se, R2 is H, HO, acyl-O, TOM-O, ACE-O, CH3-Se, alkyl-O, TBDMS-O, TMS-O, HSe, diselenide, alkyl-Se, phosphoramidite, phosphoroselenoamidite, phosphate, phosphoroselenoate, a 5'linked nucleotide, a 5'linked seleno-nucleotide, a 5'linked oligonucleotide, a 5'linked seleno-oligonucleotide, a 5'linked nucleic acid chain, or a 5'linked seleno-nucleic acid chain, R3 is H, HO, acyl-O, alkyI-O)3Si-O, BzH-O, DOD-O, alkyl-O, TBDMS-O, HSe, diselenide, alkyl-Se, DMTr- O, phosphate, phosphoroselenoate, diphosphate, diphosphoroselenoate, triphosphate, triphosphoroselenoate, a 3'linked nucleotide, a 3'linked oligonucleotide, a 3'linked nucleotide, a 3'linked oligonucleotide, or a nucleic acid chain, R4 is H or CH3, and X is an oxygen atom or selenium atom.

Oxygen replacement with selenium at the thymidine 4-position for the Se base pairing and crystal structure studies

The T-A and C-G base pairing and stacking allow the formation of the stable DNA duplex structure for genetic information storage, transcription, and replication. To replace the oxygen of the nucleotide nucleobases with selenium for the studies of the base

Synthesis of Oligodeoxyribonucleotides Containing Oleylamine Moieties

A method for directional introduction of oleylamine residues to any position of oligodeoxyribonucleotides during their automated synthesis was developed. The presence of oleylamine residues in 3′- or 5′-terminal nucleotides was shown to have no effect on