1094172-73-2Relevant articles and documents
Synthetic studies on dragmacidin D: Synthesis and assembly of three fragments towards an advanced intermediate
Oikawa, Masato,Ikoma, Minoru,Sasaki, Makoto
, p. 4654 - 4666 (2011/10/03)
We report herein the approach to the key advanced intermediate in the synthesis of the bioactive marine natural product dragmacidin D. By employing a modular synthesis strategy of three fragments (5, 7, and 8), the advanced intermediate 3 has been successfully synthesized in 2.5% yield over 15 steps by starting from nitrotoluene 20. The synthesis also involves sequential cross-coupling reactions, namely Sonogashira and Suzuki-Miyaura reactions, so that various analogues can be efficiently synthesized, which will allow the study of structure-activity relationships of dragmacidin D.
Synthetic studies on dragmacidin D: synthesis of the left-hand fragment
Ikoma, Minoru,Oikawa, Masato,Sasaki, Makoto
scheme or table, p. 7197 - 7199 (2009/04/11)
We report a synthesis of a left-hand fragment of bis(indole)-class marine alkaloid, dragmacidin D. The synthesis features Suzuki-Miyaura reaction for the coupling of imidazolyl boronic acid and (4-indolyl)vinyl bromide.