109423-09-8

Basic information

• Product Name: 1,3,5-Triazine, 1,3,5-tris(4-fluorophenyl)hexahydro-
• CAS NO: 109423-09-8
• Molecular Formula: C21H18F3N3
• Molecular Weight: 369.389
• Mol File: 109423-09-8.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1,3,5-Triazine, 1,3,5-tris(4-fluorophenyl)hexahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Triazine, 1,3,5-tris(4-fluorophenyl)hexahydro-(109423-09-8)
• EPA Substance Registry System: 1,3,5-Triazine, 1,3,5-tris(4-fluorophenyl)hexahydro-(109423-09-8)

Safety Data

• Hazardous Substances Data: 109423-09-8(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 132606-28-1 1,1-bis(hydroperoxy)cyclopentane 
• 371-40-4 4-fluoroaniline 
• 352018-71-4 cycloheptane-1,1-diyl bis-hydroperoxide 
• 2699-11-8 1,1-dihydroperoxycyclohexane 
• 229323-97-1 2,2-dihydroperoxyadamantane 

Downstream Products

• 10197-51-0 N¹,N²-bis(4-fluorophenyl)oxalamide 
• 109423-15-6 Trifluoro-acetic acid [(4-fluoro-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-methyl ester 
• 129367-32-4 [(4-Fluoro-phenylamino)-methyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Green chemical synthesis of fluorinated 1,3,5-triaryl-s-triazines in aqueous medium under microwaves as potential antifungal agents

Reasonable pure fluorinated s-triazines were synthesized in quantitative yield (96-99%) in 2-3 min in aqueous medium under microwaves, by reaction of fluorinated anilines and aqueous formaldehyde. All synthesized compounds have been screened in vitro for

Synthesis of Diversely Substituted Imidazolidines via [3+2] Cycloaddition of 1,3,5-Triazinanes with Donor-Acceptor Aziridines and Their Anti-Tumor Activity

A Y(OTf)3-catalyzed [3+2] cycloaddition of 1,3,5-triazinanes with donor-acceptor aziridines has been developed, accessing diversely substituted imidazolidines high efficiency. Mechanistic investigations support the formation of imidazolidines through an SN1-like pathway. Furthermore, these imidazolidines exhibit promising anti-tumor activity against a series of human cancer cell lines. (Figure presented.).

Synthesis of α-Amino Tertiary Alkylperoxides by Lewis Acid-Catalyzed Peroxidation of 1,3,5-Triazines

α-Substituted peroxides have been found in natural products and are widely used as anti-malarial agents. Zn(OTf)2-catalyzed peroxidation of 1,3,5-triazines has been developed, accessing diversely substituted α-amino tertiary alkylperoxides with high efficiency. Mechanistic investigations and useful synthetic application of the products have also been presented.

Iridium-catalyzed 1,5-(aryl)aminomethylation of 1,3-enynes by alkenyl-to-allyl 1,4-iridium(i) migration

A novel multicomponent coupling reaction involving the iridium-catalyzed 1,5-difunctionalization of 1,3-enynes with arylboronic acids and triazinanes is described. A key step in this 1,5-(aryl)aminomethylation reaction is the alkenyl-to-allyl 1,4-iridium(i) migration.