2699-11-8Relevant articles and documents
Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers
Amewu, Richard K.,Chadwick, James,Hussain, Afthab,Panda, Somnath,Rinki, Rinki,Janneh, Omar,Ward, Stephen A.,Miguel, Candel,Burrell-Saward, Hollie,Vivas, Livia,O'Neill, Paul M.
, p. 7392 - 7397 (2013)
The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines.
A new method for the synthesis of bishydroperoxides based on a reaction of ketals with hydrogen peroxide catalyzed by boron trifluoride complexes
Terent'ev, Alexander O.,Kutkin, Alexander V.,Platonov, Maxim M.,Ogibin, Yuri N.,Nikishin, Gennady I.
, p. 7359 - 7363 (2003)
A reaction of cycloalkanone, alkanone and alkyl aryl ketone ketals with H2O2 catalyzed by boron trifluoride etherate and boron trifluoride-methanol complexes was studied. A new versatile method for the synthesis of bishydroperoxides and their derivatives, viz. 1,1′ -dihydroperoxyperoxides and 1,2,4,5-tetraoxacyclohexanes, was developed based on this reaction.
Synthesis, Antimalarial Activity Evaluation and Molecular Docking Studies of Some New Substituted Spiro-1,2,4,5-Tetraoxane Derivatives
Chetia, Dipak,Kumawat, Mukesh Kumar
, p. 814 - 820 (2021/11/26)
Eight new substituted spiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine sensitive (3D7) and chloroquine resistant (RKL-9) strains of Plasmodium falciparum. These substituted spiro-1,2,4,5-tetraoxane derivatives were studied by molecular docking analysis in the active site of Falcipain-2 as a putative protein. Most of the synthesized compounds exhibited moderate to very good activity toward the parasite in comparison to the standard drug, chloroquine. Three compounds showed potent antimalarial activity against chloroquine sensitive strain of P. falciparum (3D7). One compound 5b (3-ethyl-3-methyl-1,2,4,5-tetraoxa-spiro[5.5]undecane) showed a very good activity against both chloroquine sensitive strain (3D7) with MIC = 1.95 ± 0.06 μg/mL and IC50 = 1.95 ± 0.06 μg/mL compared to chloroquine (MIC = 0.4 ± 0.10 μg/mL, IC50 = 0.04 ± 0.01 μg/mL) as well as chloroquine-resistant strain of P. falciparum (RKL-9) with MIC = 15.63 ± 0.70 μg/mL and IC50 = 3.90 ± 0.09 μg/mL compared to chloroquine (MIC = 25.00 ± 0.20 μg/mL, IC50 = 0.39 ± 0.02 μg/mL). The top scored compounds having low binding energy interact with the active site of Falcipain-2 in molecular docking studies.
Perhydrolysis in Ethereal H2O2 Mediated by MoO2(acac)2: Distinct Chemoselectivity between Ketones, Ketals, and Epoxides
An, Xiaosheng,Zha, Qinghong,Wu, Yikang
supporting information, p. 1542 - 1546 (2019/02/26)
Ketones, ketals, and epoxides were converted into corresponding hydroperoxides in high yields by reaction with ethereal H2O2 in the presence of a catalytic amount of MoO2(acac)2 with distinct (to date unattainable) chemoselectivity.
