109430-97-9Relevant articles and documents
Dinuclear zinc-catalyzed asymmetric desymmetrization of acyclic 2-substituted-1,3-propanediols: A powerful entry into chiral building blocks
Trost, Barry M.,Malhotra, Sushant,Mino, Takashi,Rajapaksa, Naomi S.
supporting information; experimental part, p. 7648 - 7657 (2009/08/19)
The asymmetric acylation of meso-2-substituted-1,3-propanediols by using an amphoteric chiral dinuclear zinc catalyst is described. It is has been demonstrated that both 2-alkyl- and 2-aryl-1,3-propanediols can be desymmetrized in high yields and enantioselectivities by using the same family of ligands. Given that both antipodes of the chiral catalyst are available, both enantiomers of the desymmetrized product can be obtained from the same starting material. The synthetic utility of the desymmetrized products has been demonstrated by the synthesis of several chiral building blocks with high enantiomeric purities.
ENANTIOMERENREINE GLYCERIN-DERIVATE DURCH ENZYMATISCHE HYDROLYSE PROCHIRALER ESTER
Kerschner, V.,Kreiser, W.
, p. 531 - 534 (2007/10/02)
A practical method for large scale preparation of optical active glycerols protected in a versatile manner is described herein.Among these the crystalline pure enantiomers V deserve highest attention, since they offer three different functionalities for s