109429-00-7Relevant articles and documents
Enzymatic Differentiation of the Enantiotopic Hydroxymethyl Groups of Glycerol; Synthesis of Chiral Building Blocks
Breitgoff, Detlev,Laumen, Kurt,Schneider, Manfred P.
, p. 1523 - 1524 (1986)
The prochiral (3b), derived from glycerol, was transformed by enantioselective, enzymatic hydrolysis into the central chiral building block (R)-(4) of high enantiometric purity, which was further elaborated into a variety of chiral building blocks with th
Hydrolases in organic synthesis: Preparation of enantiomerically pure compounds
Ader, U,Andersch, P,Berger, M,Goergens, U,Seemayer, R,Schneider, M
, p. 145 - 150 (2007/10/02)
Esterhydrolases (Esterases, Lipases) are highly (chemo-, regio- and enantio-) selective biocatalysts for the transformation of racemic and achiral substrates into enantiomerically pure compounds.Numerous examples for their application in the preparation of synthetically useful chiral auxiliaries and building blocks for flavour compounds, pheromones and several pharmaceuticals including β-adrenergic blockers, antidepressants and ACE inhibitors are presented.
Efficient Lipase-Catalyzed Synthesis of Chiral Glycerol Derivatives
Murata, Masakazu,Terao, Yoshiyasu,Achiwa, Kazuo,Nishio, Tishiyuki,Seto, Kazumaro
, p. 2670 - 2672 (2007/10/02)
Efficient asymmetric syntheses of glycerol derivatives were achieved by lipase-catalyzed transesterification. 2-O-Substituted glycerol was enzymatically esterified with acetic acid or acetate in an organic medium to afford an optically active monoester.In