109466-23-1

Basic information

• Product Name: 5H-CHROMENO[4,3-D]PYRIMIDIN-2-AMINE
• Synonyms: 5H-CHROMENO[4,3-D]PYRIMIDIN-2-AMINE;5H-CHROMENO[4,3-D]PYRIMIDIN-2-YLAMINE
• CAS NO: 109466-23-1
• Molecular Formula: C11H9N3O
• Molecular Weight: 199.21
• Mol File: 109466-23-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5H-CHROMENO[4,3-D]PYRIMIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-CHROMENO[4,3-D]PYRIMIDIN-2-AMINE(109466-23-1)
• EPA Substance Registry System: 5H-CHROMENO[4,3-D]PYRIMIDIN-2-AMINE(109466-23-1)

Safety Data

• Hazardous Substances Data: 109466-23-1(Hazardous Substances Data)

Upstream product

• 50-01-1 guanidine hydrochloride 
• 74396-87-5 3-(Dimethylaminomethylene)-4-chromanone 
• 39513-78-5 pyrrolidinomethylene-3 chromanone-4 
• 113-00-8 guanidine nitrate 

Relevant articles and documents

New polycyclic pyrimidine derivatives with antiplatelet in vitro activity: Synthesis and pharmacological screening

The preparation and the pharmacological screening of novel anti-aggregatory/antiphlogistic polycyclic pyrimidine derivatives are described. The compounds were developed starting from bioactive 2-aminobenzopyranopyrimidine derivatives in order to assess the importance of the benzopyrano[4,3-d]pyrimidine structure and the role of an amino basic moiety in position 2. Antiplatelet activity was assessed in vitro against ADP and arachidonic acid-induced aggregation in guinea-pig plasma. Anti-inflammatory/analgesic/antipyretic activities were studied in rat paw oedema, mouse writhing test and E coli-induced rat fever. Ulcerogenic and gastroprotective effects were also investigated in vivo on rat gastric mucosa. Among the tested compounds, the 5-substituted benzopyranopyrimidine derivatives 3d and 4d proved to be the most active antiplatelet agents as potent as acetylsalicylic acid against arachidonic acid-stimulated aggregation. Furthermore the 2-methylthio derivative 4d was endowed with greater efficacy against ADP aggregation suggesting that additional non-TXA2 dependent mechanisms are involved in its biological activity. Orally administered at 100mgkg-1 in rats this latter compound displayed antiphlogistic acitivity comparable to indomethacin (10 mg kg -1) coupled with an unusual gastroprotective effect on ethanol-induced ulcers. In conclusion, these findings indicate that the 5-pyrrolidino-2-methylthiobenzopyrano[4,3-d]pyrimidine 4d fulfils the chemical requirements to exhibit antiplatelet activity associated with gastroprotective effect. Copyright