109507-03-1Relevant articles and documents
A arylpyrimidines and its derivatives preparation method (by machine translation)
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Paragraph 0068, (2016/11/14)
This invention has offered a kind of arylpyrimidines and process for preparing derivatives thereof, comprising the following steps: S1) shown in the formula (II) 2 the iminium salts dial two substituted propionic [...], shown in formula (III) compound with a nitrile group of alkaline catalyst 1st reaction in the organic solvent, get mixed solution; S2) in the mixed solution is added with ammonium salt and 2nd alkaline catalyst, for the reaction, formula (I) shown in the arylpyrimidines and its derivatives. Compared with the prior art, this invention is in the presence of the alkaline catalyst, 2 the iminium salts dial two substituted propionic [...], of nitrile compounds and ammonium salt [3+2 + 1] ternary cyclization reaction to construct a pyrimidine ring, in order to get arylpyrimidines and its derivatives, this method does not use the noble metal catalyst, line is simple, low cost, high controllability of the process, easy industrialization, reduces the waste of relatively high yield and emissions. (by machine translation)