109526-42-3Relevant academic research and scientific papers
Enzymatic resolution of diethyl 3-hydroxycycloalkenyl phosphonates
Attolini, Mireille,Iacazio, Gilles,Peiffer, Gilbert,Charmasson, Yolande,Maffei, Michel
, p. 827 - 830 (2004)
Enantiomerically pure cyclic (S)-diethyl 3-hydroxy-1-alkenyl phosphonates 1-3 were obtained by enzymatic resolutions. The corresponding (R)-acetates were also obtained with high enantiomeric excess, except in the case of the five-membered ring compound. T
Radiosynthesis and Evaluation of [11C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites
Jensen, Claus H.,Hansen, Hanne D.,Bay, Tina,Vogensen, Stine B.,Lehel, Szabolcs,Thiesen, Louise,Bundgaard, Christoffer,Clausen, Rasmus P.,Knudsen, Gitte M.,Herth, Matthias M.,Wellendorph, Petrine,Fr?lund, Bente
, p. 22 - 27 (2017)
γ-Hydroxybutyric acid (GHB) is an endogenous neuroactive substance and proposed neurotransmitter with affinity for both low- and high-affinity binding sites. A radioligand with high and specific affinity toward the high-affinity GHB binding site would be
New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites
Vogensen, Stine B.,Marek, Ale?,Bay, Tina,Wellendorph, Petrine,Kehler, Jan,Bundgaard, Christoffer,Fr?lund, Bente,Pedersen, Martin H. F.,Clausen, Rasmus P.
, p. 8201 - 8205 (2013)
3-Hydroxycyclopent-1-enecarboxylic acid (HOCPCA, 1) is a potent ligand for the high-affinity GHB binding sites in the CNS. An improved synthesis of 1 together with a very efficient synthesis of [3H]-1 is described. The radiosynthesis employs in
Radiolabeled HOCPCA as a highly useful tool in drug discovery and pharmacology
Griem-Krey, Nane,Fr?lund, Bente,Marek, Ale?,Wellendorph, Petrine
, p. 77 - 81 (2021)
GHB (γ-hydroxybutyrate) is not only an endogenously present small molecule but also a clinically prescribed drug for the symptomatic treatment of narcolepsy. However, GHB's mechanism of action remains to be uncovered. Within the CNS, GHB targets both GABA
Synthesis of ACE tricyclic systems of daphnicyclidin A and dehy-droxymacropodumine A
Wang, Qi,Zhang, Chao,Yang, Jun
supporting information, p. 1906 - 1910 (2019/12/27)
The synthesis of the ACE tricyclic system of daphnicyclidin A and dehydroxymacropodumine A are developed. The key reactions include an efficient aldol reaction to introduce chiral fragment 33 for further construction of piperidine ring B and seven-membered ring C, a nucleophilic addition of lithium pentene to aldehyde for installation of ring E, and a photocatalytic decarboxylation conjugate addition to construct ring C.
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas
McBriar, Mark D.,Guzik, Henry,Shapiro, Sherry,Paruchova, Jaroslava,Xu, Ruo,Palani, Anandan,Clader, John W.,Cox, Kathleen,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian D.,Weig, Blair,Weston, Daniel J.,Farley, Constance,Cook, John
, p. 2294 - 2310 (2007/10/03)
Melanin-concentrating hormone (MCH) is a cyclic, nonadecapeptide expressed in the CNS of all vertebrates that regulates feeding behavior and energy homeostasis via interaction with the central melanocortin system. Regulation of this interaction results in
Preparation of chiral allylic alcohols using Rhizopus nigricans. Use of the Harada-Nakanishi exciton chirality method for verifying configurational assignments of allylic alcohols
Ito, Satoru,Kasai, Masaji,Ziffer, Herman,Silverton, J.V.
, p. 574 - 582 (2007/10/02)
A series of (R) acyclic and cyclic allylic alcohols was prepared by enantioselective hydrolysis of acetates using Rhizopus nigricans.The configurations of the alcohols formed were established by chemical methods and, in the case of 1,2-benzocyclohepta-1,3
