109546-07-8

Basic information

• Product Name: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide
• Synonyms: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide;Cibenzoline IMpurity (N-(2-aMinoethyl-2,2-diphenyl CyclopropanecarboxaMide)
• CAS NO: 109546-07-8
• Molecular Formula: C18H20N2O
• Molecular Weight: 280.3642
• Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 109546-07-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(109546-07-8)
• EPA Substance Registry System: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(109546-07-8)

Safety Data

• Hazardous Substances Data: 109546-07-8(Hazardous Substances Data)

Usage

Uses

N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide is an intermediate in the synthesis of Cibenzoline (Cifenline).

Upstream product

• 149030-24-0 (1R)-1,1-diphenyl-2-hydroxymethylcyclopropane 
• 926905-41-1 2,2-diphenylcyclopropane-1-carbaldehyde 
• 53692-74-3 (R)-2,2-diphenylcyclopropanecarboxylic acid 
• 107-15-3 ethylenediamine 
• 57625-97-5 Cibenzoline succinate 
• 4801-14-3 3,3-diphenylprop-2-en-1-ol 

Downstream Products

• 103419-18-7 [14C]-(+)-Cibenzoline 
• 103419-18-7 [14C]-(-)-Cibenzoline 

Relevant articles and documents

Kinetics and mechanism of the hydrolysis of a 2-substituted imidazoline, cibenzoline (cifenline)

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Syntheses of (R)-(+)-cibenzoline and analogues via catalytic enantioselective cyclopropanation using (S)-phenylalanine-derived disulfonamide

Cyclopropanation of 3,3-diaryl-2-propen-1-ols 1 with Et2Zn and CH2I2 proceeded in the presence of a catalytic amount of (S)-2-(methanesulfonyl)amino-1-(p-toluenesulfonyl)amino-3-phenylpropane 2 to afford the corresponding