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109546-07-8

N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, which includes an aminoethyl group attached to a cyclopropanecarboxamide core, with two phenyl rings in the 2,2-position. This structure endows the compound with specific chemical properties that make it valuable in the development of certain medications.

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  • Cibenzoline Impurity (N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide)

    Cas No: 109546-07-8

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  • Cibenzoline Impurity (N-(2-aminoethyl-2,2-diphenyl Cyclopropanecarboxamide)

    Cas No: 109546-07-8

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  • 109546-07-8 Structure

  • Basic information

    1. Product Name: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide
    2. Synonyms: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide;Cibenzoline IMpurity (N-(2-aMinoethyl-2,2-diphenyl CyclopropanecarboxaMide)
    3. CAS NO:109546-07-8
    4. Molecular Formula: C18H20N2O
    5. Molecular Weight: 280.3642
    6. EINECS: N/A
    7. Product Categories: Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 109546-07-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
    9. CAS DataBase Reference: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(109546-07-8)
    11. EPA Substance Registry System: N-(2-AMinoethyl)-2,2-diphenylcyclopropanecarboxaMide(109546-07-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 109546-07-8(Hazardous Substances Data)

109546-07-8 Usage

Uses

Used in Pharmaceutical Synthesis:
N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide is used as an intermediate in the synthesis of Cibenzoline (Cifenline), a medication primarily utilized in the treatment of hypertension. Its role in the synthesis process is to provide the necessary structural framework for the final drug, contributing to its therapeutic effects.
Used in Chemical Research:
In addition to its pharmaceutical applications, N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide may also be employed in chemical research for the development of new compounds with potential applications in various fields. Its unique structure allows for further modification and exploration of its properties, potentially leading to the discovery of novel substances with beneficial characteristics.
Used in Drug Delivery Systems:
Similar to gallotannin, N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide could potentially be used in the development of drug delivery systems. Its structural properties may allow for the creation of innovative carriers or enhancers for other pharmaceutical compounds, improving their delivery, bioavailability, and overall therapeutic outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 109546-07-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,5,4 and 6 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 109546-07:
(8*1)+(7*0)+(6*9)+(5*5)+(4*4)+(3*6)+(2*0)+(1*7)=128
128 % 10 = 8
So 109546-07-8 is a valid CAS Registry Number.

109546-07-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2-Aminoethyl)-2,2-diphenylcyclopropanecarboxamide

1.2 Other means of identification

Product number -
Other names N-(2-aminoethyl)-2,2-diphenylcyclopropane-1-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109546-07-8 SDS

109546-07-8Relevant articles and documents

Convenient preparation of optically active cibenzoline and analogues from 3,3-diaryl-2-propen-1-ols

Koyata, Naka,Miura, Tsuyoshi,Akaiwa, Yoko,Sasaki, Hisashi,Sato, Rie,Nagai, Takuya,Fujimori, Hirohisa,Noguchi, Takuya,Kirihara, Masayuki,Imai, Nobuyuki

experimental part, p. 2065 - 2071 (2010/01/16)

(R)-(+)-Cibenzoline (95% ee) was synthesized in two steps from (+)-2,2-diphenylcyclopropylmethanol 3a (98% ee), which was oxidized with IBX in DMSO, followed by treatment with ethylenediamine in the presence of I2 and K2CO3/sub

Syntheses of (R)-(+)-cibenzoline and analogues via catalytic enantioselective cyclopropanation using (S)-phenylalanine-derived disulfonamide

Miura, Tsuyoshi,Murakami, Yasuoki,Imai, Nobuyuki

, p. 3067 - 3069 (2007/10/03)

Cyclopropanation of 3,3-diaryl-2-propen-1-ols 1 with Et2Zn and CH2I2 proceeded in the presence of a catalytic amount of (S)-2-(methanesulfonyl)amino-1-(p-toluenesulfonyl)amino-3-phenylpropane 2 to afford the corresponding

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