103419-18-7Relevant articles and documents
Novel Process For The Preparation Of (-)-Cibenzoline Succinate
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, (2020/08/11)
The present invention relates to a crystalline form of (-)-cibenzoline succinate. The present invention also relates to a method for manufacturing (-)-cibenzoline succinate having a chiral purity of 99.9% or higher. In addition, the present invention provides the method for manufacturing (-)-cibenzoline succinate and a crystalline form thereof. The (-)-cibenzoline succinate according to the present invention is economical and remarkably advantageous for mass production.COPYRIGHT KIPO 2020
Convenient preparation of optically active cibenzoline and analogues from 3,3-diaryl-2-propen-1-ols
Koyata, Naka,Miura, Tsuyoshi,Akaiwa, Yoko,Sasaki, Hisashi,Sato, Rie,Nagai, Takuya,Fujimori, Hirohisa,Noguchi, Takuya,Kirihara, Masayuki,Imai, Nobuyuki
experimental part, p. 2065 - 2071 (2010/01/16)
(R)-(+)-Cibenzoline (95% ee) was synthesized in two steps from (+)-2,2-diphenylcyclopropylmethanol 3a (98% ee), which was oxidized with IBX in DMSO, followed by treatment with ethylenediamine in the presence of I2 and K2CO3/sub
Syntheses of (R)-(+)-cibenzoline and analogues via catalytic enantioselective cyclopropanation using (S)-phenylalanine-derived disulfonamide
Miura, Tsuyoshi,Murakami, Yasuoki,Imai, Nobuyuki
, p. 3067 - 3069 (2007/10/03)
Cyclopropanation of 3,3-diaryl-2-propen-1-ols 1 with Et2Zn and CH2I2 proceeded in the presence of a catalytic amount of (S)-2-(methanesulfonyl)amino-1-(p-toluenesulfonyl)amino-3-phenylpropane 2 to afford the corresponding