109581-83-1

Basic information

• Product Name: N-ACETYL-1-CHLORO-3,4,6-TRI-O-ACETYL-GALACTOSAMINIDE
• Synonyms: N-ACETYL-1-CHLORO-3,4,6-TRI-O-ACETYL-GALACTOSAMINIDE;2-(Acetylamino)-2-deoxy-D-galactopyranosyl chloride 3,4,6-triacetate
• CAS NO: 109581-83-1
• Molecular Formula: C₁₄H₂₀ClNO₈
• Molecular Weight: 380.75496
• Mol File: 109581-83-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 516.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 13.22±0.70(Predicted)
• CAS DataBase Reference: N-ACETYL-1-CHLORO-3,4,6-TRI-O-ACETYL-GALACTOSAMINIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-1-CHLORO-3,4,6-TRI-O-ACETYL-GALACTOSAMINIDE(109581-83-1)
• EPA Substance Registry System: N-ACETYL-1-CHLORO-3,4,6-TRI-O-ACETYL-GALACTOSAMINIDE(109581-83-1)

Safety Data

• Hazardous Substances Data: 109581-83-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 66-84-2 D-(+)-glucosamine hydrochloride 
• 14131-68-1 N-acetyl-D-glucosamine 
• 75-36-5 acetyl chloride 
• 75-34-3 1,1-dichloroethane 
• 14131-63-6 D-glucosamine hydrochloride 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 3006-60-8 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-galactopyranose 
• 72-87-7 N-acetyl-D-galactosamine 

Downstream Products

• 86520-53-8 2-[2-(2-Azidoethoxy)ethoxy]ethyl 3,4,6-tri-O-acetyl-2-N-acetamido-2-deoxy-β-D-glucopyranoside 
• 6205-69-2 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl azide 
• 61145-37-7 2-N-acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio(S-cyanomethyl)-β-D-glucopyranoside 
• 61145-38-8 S-cyanomethyl 2-N-acetamido-2-deoxy-1-thio-β-D-glucopyranoside 
• 29847-23-2 2-N-acetylamido-2-deoxy-β-D-glucopyranosyl azide 
• 131287-39-3 N^ω-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-N^α-(9-fluorenylmethyloxycarbonyl))-L-asparagine 
• 146288-30-4 pentyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranoside 
• 94483-64-4 Pentyl 2-acetamido-2-deoxy-β-D-glucopyranoside 
• 74034-09-6 2-acetamido-1,5-anhydro-4,6-O-benzylidene-2-deoxy-D-glucitol 
• 7512-17-6 N-Acetyl-D-glucosamine 
• 20590-45-8 3,4,6-tri-O-acetyl-2-N-acetylamido-2-deoxy-β-D-glucopyranosyl isothiocyanate 

Relevant articles and documents

IN VIVO ASSEMBLY OF ASGPR BINDING THERAPEUTICS

Compounds are provided that assemble together in vivo to form an ASGPR-binding compound that has an asialoglycoprotein receptor (ASGPR) binding ligand bound to an extracellular protein binding ligand for the selective degradation of the target extracellular protein in vivo to treat disorders mediated by the extracellular protein.

NOVEL IMMUNODULATING SMALL MOLECULES

The present invention includes novel compositions and methods for treating comprising a compound with the Formula I: where n = 0-5; X = NH, O, S, CH2; Y = Phenyl, a phenyl group substituted with at least one methyl, a phenyl group substituted with at least one nitro, a phenyl group substituted with at least one nitrogen, a phenyl group substituted with at least one boron, aryl, substituted aryl, heteroaryl, four to six membered cycloalkyl, four to six membered heterocycloalkyl; R = H, C(O)R2, SO2R2; R1 = H, C(O)R2, SO2R2; R2 = Ethyl, methyl, isopropyl, n-propyl, t-butyl, n- butyl, NH2, NR3R4; R3, R4 = Ethyl, methyl, isopropyl, n-propyl, t-butyl, n-butyl, three to six membered cycloalkyl and Z = NH, O, S, CH2 or none, wherein the amount of the compound is selected to either inhibit or activate the immune response.

Synthesis and biological evaluation of novel C1-glycosyl thiazole derivatives as acetylcholinesterase inhibitors

A new series of C1-glycosyl thiazole derivatives was synthesised by the reaction of 1-(1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranos-2-yl)thiourea with 2-bromoacetophenone derivatives. Subsequent removal of the acetyl groups were conducted using NaOMe-MeOH. The structures of all new products were confirmed by IR, 1H NMR and HRMS (ESI). The acetylcholinesterase inhibitory activities of these new compounds were tested. Among them, N-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-4-(4-nitrophenyl)-1,3-thiazole-2-amine showed the best activity with an inhibition rate of 43.21%.