1096141-54-6

Basic information

• Product Name: 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile
• Synonyms: 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile
• CAS NO: 1096141-54-6
• Molecular Weight: 371.277
• Mol File: 1096141-54-6.mol

Chemical Properties

• CAS DataBase Reference: 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile(1096141-54-6)
• EPA Substance Registry System: 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile(1096141-54-6)

Safety Data

• Hazardous Substances Data: 1096141-54-6(Hazardous Substances Data)

Usage

Molecular structure

The chemical has a 1H-indole core with a 5-bromo substitution, a 7-carbonitrile group, and a benzyloxypropyl side chain.

Application

It is used in research and development as a building block for the synthesis of various pharmaceuticals and agrochemicals.

Potential applications

It may have potential applications in medicinal chemistry and drug discovery due to its structural features and potential biological activity.

Safety

It is important to handle this chemical with caution and in accordance with proper safety protocols due to its potential risks and hazards.

Upstream product

• 496-15-1 1-indoline 
• 115661-82-0 7-cyanoindoline 
• 1096141-53-5 5-bromo-7-indolinecarbonitrile 
• 54314-84-0 1-[(3-bromopropoxy)methyl]-benzene 

Downstream Products

• 1423218-40-9 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 1096141-50-2 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile 

Relevant articles and documents

Convergent synthesis of (R)-silodosin via decarboxylative cross-coupling

A new approach to Silodosin capitalizing on a radical retrosynthetic strategy to dissect the molecule into two halves is reported. Using a reductive decarboxylative cross-coupling, a simple indoline can be coupled to a chiral pool-derived fragment to arrive at the target in only seven steps (LLS). This route avoids the use of resolution strategies or asymmetric hydrogenation that requires a subsequent Curtius rearrangement to install a key amino functionality.

PROCESS FOR THE PREPARATION OF SILODOSIN

The present invention relates to a new process of preparation of Silodosin, or a pharmaceutically acceptable salt thereof. Another aspect of the invention concerns compounds of formula II: or their pharmaceutically acceptable salts thereof, and their use for the preparation of Silodosin or a pharmaceutically acceptable salt thereof.

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE

The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.