1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile

Base Information

Chemical Name:1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile
CAS No.:1096141-54-6
Molecular Formula:C₁₉H₁₉BrN₂O
Molecular Weight:371.277
Hs Code.:
Mol file:1096141-54-6.mol

Synonyms:1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile

Suppliers and Price of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile

There total 3 articles about 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-bromo-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1096141-53-5
5-bromo-7-indolinecarbonitrile

: 54314-84-0
1-[(3-bromopropoxy)methyl]-benzene

: 1096141-54-6
1-(3-(benzyloxy)propyl)-5-bromoindoline-7-carbonitrile

Guidance literature:: 5-bromoindoline-7-carbonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

1-[(3-bromopropoxy)methyl]-benzene; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 6h;
DOI:10.1016/j.tetlet.2021.153290

Reference yield:

: 115661-82-0
7-cyanoindoline

: 1096141-54-6
1-(3-(benzyloxy)propyl)-5-bromoindoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / dichloromethane / 5 h / 0 - 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 6 h / 20 °C

With N-Bromosuccinimide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetlet.2021.153290

Reference yield:

: 496-15-1
1-indoline

: 1096141-54-6
1-(3-(benzyloxy)propyl)-5-bromoindoline-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trichloride / toluene / 1 h / 0 °C / Reflux

1.2: 8.33 h / 75 - 85 °C

1.3: 49 h / Alkaline conditions

2.1: N-Bromosuccinimide / dichloromethane / 3 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

3.2: 6 h / 20 °C

With N-Bromosuccinimide; boron trichloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;