109667-69-8

Upstream product

• 18942-49-9 Boc-D-Phe-OH 
• 112271-08-6 C₁₈H₂₅NO₅ 
• 1247065-61-7 C₁₇H₂₁N₃O₃ 
• 112700-42-2 (5R)-5-Benzyl-1-tert-butyloxycarbonyl-4-hydroxy-1,5-dihydropyrrol-2-one 
• 4530-18-1 2-tert-Butoxycarbonylamino-3-phenyl-propionic acid 
• 112700-37-5 5-[(2R)-2-(tert-Butoxycarbonylamino)-1-hydroxy-3-phenylpropylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 148982-85-8 {(1R,2R)-1-Benzyl-2-hydroxy-3-[2-(1H-imidazol-2-yl)-ethylcarbamoyl]-propyl}-carbamic acid tert-butyl ester 
• 149057-14-7 [(1R,2R)-1-Benzyl-2-hydroxy-3-((S)-2-hydroxy-1-phenyl-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 148982-70-1 (1'R,2'R)-N-<1-<2-hydroxy-4-oxo-4-<(2-methylpropyl)amino>-1-(phenylmethyl)butyl>>carbamic acid 1,1-dimethylethyl ester 
• 150935-33-4 [(1R,2R)-1-Benzyl-2-hydroxy-3-(2-hydroxy-ethylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 151005-56-0 [(1R,2R)-1-Benzyl-2-hydroxy-3-(3-hydroxy-propylcarbamoyl)-propyl]-carbamic acid tert-butyl ester 
• 150935-30-1 ((1R,2R)-1-Benzyl-3-benzylcarbamoyl-2-hydroxy-propyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

NOVEL MULTIFUNCTIONAL PEPTIDASE INHIBITORS, ESPECIALLY FOR MEDICAL USE

The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.

Novel multifunctional peptidase inhibitors, especially for medical use

The invention relates to compounds of the general formula (1) or the acid addition salts thereof with organic and/or inorganic acids; as well as to the use of the compounds of the general formula (1) in medicine.

Process for the stereospecific synthesis of optically pure 4-amino-3-hydroxycarboxylic acid derivatives

The process described makes it possible to obtain optically pure 4-amino-3-hydroxycarboxylic acids by means of a series of stereoselective steps. The starting material is an alpha-amino acid in the L or D configuration, with which Meldrum's acid is reacted. The resulting pyrrolone derivative is reduced prior to opening of the pyrrolidine ring. The invention also relates to the new products obtained by the said process and to the pyrrolone derivatives obtained as intermediates.

Stereospecific Synthesis of N-Protected Statine and Its Analogues via Chiral Tetramic Acid

The condensation of a chiral N-protected amino acid with Meldrum's acid in the presence of isopropenyl chloroformate (IPCF) and of 4-N,N-dimethylaminopyridine (DMAP) has been examined.The cyclisation of the reaction product, by heating in an organic solve