112700-42-2

Upstream product

• 112700-37-5 5-[(2R)-2-(tert-Butoxycarbonylamino)-1-hydroxy-3-phenylpropylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1282523-16-3 C₂₀H₂₇NO₇ 
• 4530-18-1 2-tert-Butoxycarbonylamino-3-phenyl-propionic acid 
• 18942-49-9 Boc-D-Phe-OH 

Downstream Products

• 109579-13-7 (4R,5R)-5-Benzyl-1-(tert-butyloxycarbonyl)-4-hydroxypyrrolidin-2-one 
• 109667-69-8 (1'R,2'R)-N-<2,4-dihydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester 
• 1282523-17-4 C₁₁H₁₁NO₂ 
• 1282523-18-5 (2'R,5R)-2',5-dibenzyl-4-hydroxy-1H,1'H-[3,3'-bipyrrole]-2,5'(2'H,5H)-dione 
• 361531-86-4 (2R,3R)-2-Benzyl-3-benzyloxy-1-(tert-butyloxycarbonyl)pyrrolidine 
• 361531-79-5 (2R,3R)-2-Benzyl-1-(tert-butyloxycarbonyl)pyrrolidin-3-ol 
• 361531-82-0 (2R)-2-Benzyl-1-(tert-butyloxycarbonyl)pyrrolidin-3-one 

Relevant academic research and scientific papers

Cytotoxic tetramic acid derivative produced by a plant type-III polyketide synthase

The tetramic acid (2,4-pyrrolidinedione) scaffold has been recognized as an important structural feature because of its mycotoxic, antibacterial, antiviral, and antioxidant activities. This important class of natural products is reportedly produced by the type-I polyketide synthase/nonribosomal peptide synthetase (PKS/NRPS) hybrid megaenzyme systems. In contrast, the benzalacetone synthase (BAS) from Rheum palmatum is a structurally simple, plant-specific type-III PKS that catalyzes the one-step decarboxylative condensation of malonyl-CoA with 4-coumaroyl-CoA. The type-III PKS exhibits unusually broad substrate specificity and notable catalytic versatility. Here we report that R. palmatum BAS efficiently produces a series of unnatural, novel tetramic acid derivatives by the condensation of malonyl-CoA with aminoacyl-CoA thioesters chemically synthesized from l- and d-amino acids. Remarkably, the novel tetramic acid dimer d-5 formed from d-phenylalanoyl-CoA showed moderate antiproliferative activity against murine leukemia P388 cells.

Design of potential new HIV protease inhibitors: Enantioconvergent synthesis of new pyrrolidin-3-ol, and pyrrolidin-3-one peptide conjugates

Novel potential HIV protease inhibitors are obtained by an enantioconvergent synthesis of mimicking Phe-Pro dipeptides, achieved through the coupling between Boc(L)Phe or Boc(L)Tyr and both enantiomers of syn-2-benzylpyrrolidin-3-ol and their correspondin

Stereospecific Synthesis of N-Protected Statine and Its Analogues via Chiral Tetramic Acid

The condensation of a chiral N-protected amino acid with Meldrum's acid in the presence of isopropenyl chloroformate (IPCF) and of 4-N,N-dimethylaminopyridine (DMAP) has been examined.The cyclisation of the reaction product, by heating in an organic solve