1097-25-2

Basic information

• Product Name: Methanone, (4-methoxyphenyl)[4-(4-methoxyphenyl)-1H-imidazol-2-yl]-
• CAS NO: 1097-25-2
• Molecular Formula: C18H16N2O3
• Molecular Weight: 308.337
• Mol File: 1097-25-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Methanone, (4-methoxyphenyl)[4-(4-methoxyphenyl)-1H-imidazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (4-methoxyphenyl)[4-(4-methoxyphenyl)-1H-imidazol-2-yl]-(1097-25-2)
• EPA Substance Registry System: Methanone, (4-methoxyphenyl)[4-(4-methoxyphenyl)-1H-imidazol-2-yl]-(1097-25-2)

Safety Data

• Hazardous Substances Data: 1097-25-2(Hazardous Substances Data)

Upstream product

• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 16208-17-6 2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one 
• 150114-69-5 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde 
• 1076-95-5 p-methoxyphenylglyoxal 
• 6595-28-4 2-azido-1-(4-methoxyphenyl)ethan-1-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 100-52-7 benzaldehyde 

Downstream Products

• 1388186-27-3 2,8-bis(4-methoxyphenyl)-6-(pyrrolidin-1-yl)imidazo[1,2-a]pyridine 
• 1388186-49-9 4-(2,8-bis(4-methoxyphenyl)imidazo[1,2-a]pyridin-6-yl)morpholine 
• 1384177-47-2 (4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanone 
• 1384177-20-1 (4-methoxyphenyl)[4-(4-methoxyphenyl)-1-(prop-2-yn-1-yl)-1H-imidazol-2-yl]methanol 
• 6595-39-7 (4‐methoxyphenyl)[4‐(4‐methoxyphenyl)‐1H‐imidazol‐2‐yl]methanol 

Relevant articles and documents

A novel structure for ESIPT emission: Experimental and theoretical investigations

A number of substituted imidazole-based molecules were synthesized via a two-step one-pot reaction and their UV/vis and fluorescence spectra were analyzed. Emissions of the imidazole-based molecules were attributed to the excited state intramolecular prot

Synthesis of imidazo-1,4-oxazinone derivatives and investigation of reaction mechanism

In this study, nine different C-2 aroyl imidazole derivatives were synthesized in a one pot reaction with two steps, and the reduction reactions of these derivatives with NaBH4 were carried out under mild conditions. Substitution reaction of obtained imid

Mono- or di-substituted imidazole derivatives for inhibition of acetylcholine and butyrylcholine esterases

Mono- or di-substituted imidazole derivatives were synthesized using a one-pot, two-step strategy. All imidazole derivatives were tested for AChE and BChE inhibition and showed nanomolar activity similar to that of the test compound donepezil and higher than that of tacrine. Structure activity relationship studies, docking studies to on X-ray crystal structure of AChE with PDB code 1B41, and adsorption, distribution, metabolism, and excretion (ADME) predictions were performed. The synthesized core skeleton was bound to important regions of the active site of AChE such as the peripheral anionic site (PAS), oxyanion hole (OH), and anionic subsite (AS). Selectivity of the reported test compounds was calculated and enzyme kinetic studies revealed that they behave as competitive inhibitors, while two of the test compounds showed noncompetitive inhibitory behavior. ADME predictions revealed that the synthesized molecules might pass through the blood brain barrier and intestinal epithelial barrier and circulate freely in the blood stream without binding to human serum albumin. While the toxicity of one compound on the WS1 (skin fibroblast) cell line was 1790 μM, its toxicity on the SH-SY5Y (neuroblastoma) cell line was 950 μM.