109715-58-4

Upstream product

• 29884-67-1 (4R,5S)-1,2,4,5,6-Pentahydroxy-hexan-3-one 
• 67-64-1 acetone 
• 25494-39-7 (+/-)-Isopropyliden-2,3-erythronsaeure-lacton 

Downstream Products

• 73346-74-4 (4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol 
• 109715-57-3 (R,R)-4-benzyloxymethyl-2,2,5-trimethyl-1,3-dioxolane 
• 91526-98-6 benzyl (4R,5R)-2,2-dimethyl-5-(2-methyl-1,3-dithian-2-ylmethyl)-1,3-dioxolan-4-ylmethyl ether 
• 91526-99-7 1-((4R,5R)-5-((benzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propane-2-one 
• 91526-97-5 (4S,5R)-5-benzyloxymethyl-4-bromomethyl-2,2-dimethyl-1,3-dioxolane 
• 78469-77-9 1-O-benzyl-2,3-O-isopropylidene-D-threitol 

Relevant academic research and scientific papers

Synthesis of dl-cis-and (4R,5R)-trans-7--5(Z)-heptenoic acid analogues as platelet thromboxane A2 receptor antagonists

The title compounds have been synthesized and their in vitro thromboxane A2(TxA2) receptor antagonist activity evaluated.Both cis and trans isomers (1,2) were shown to specifically inhibit submaximal human platelet aggregation induced by 225 nM U46619 in a dose-dependent manner with an IC50 of 1 μM.The concentration of 1 and 2 required to completely block maximal aggregation induced by 3 μM U46619 was 3 μM. thromboxane A2/ receptor antagonist/ platelet aggregation/ 1,3-dioxolane

Aldol Reaction between Small Sugars. Preparation of DL-threo-2-Pentulose and DL-lyxo-3-Hexulose and their Isolation as O-Isopropylidene Derivatives

The improved diastereoselectivity obtained with strongly basic anion-exchange resin as catalyst in aldol condensation between two-, three- and four-carbon "sugars" has been utilised in the preparation of DL-threo-2-pentulose and DL-lyxo-3-hexulose, which were isolated as their O-isopropylidene derivatives.A possible reason for the observe preference of formation of the lyxo-diastereomer in condensation between glycolaldehyde and glycero-tetrulose is suggested.