European Journal of Medicinal Chemistry p. 321 - 326 (1995)
Update date:2022-09-26
Topics:
Komiotis, D.
Pananookooln, S.
Zaw, K.
Dieter, J. P.
Breton, G. C. Le
Venton, D. L.
The title compounds have been synthesized and their in vitro thromboxane A2(TxA2) receptor antagonist activity evaluated.Both cis and trans isomers (1,2) were shown to specifically inhibit submaximal human platelet aggregation induced by 225 nM U46619 in a dose-dependent manner with an IC50 of 1 μM.The concentration of 1 and 2 required to completely block maximal aggregation induced by 3 μM U46619 was 3 μM. thromboxane A2/ receptor antagonist/ platelet aggregation/ 1,3-dioxolane
View MoreTengzhou Runlong Fragrance Co., Ltd.
website:http://www.tzrunlong.com/
Contact:--
Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
Hangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
website:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Wuhan Chemchemical Co., Ltd.(expird)
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
MTT Pharma & Bio-technology Co.,Ltd(expird)
Contact:+86-21-58407925
Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
Doi:10.1016/S0040-4039(00)85246-6
(1986)Doi:10.1039/c39900000897
(1990)Doi:10.1039/c2ob06934b
(2012)Doi:10.1007/BF00487436
(1990)Doi:10.1021/ol2011067
(2011)Doi:10.1016/0022-328X(86)82021-6
(1986)
