109740-09-2

Basic information

• Product Name: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE
• Synonyms: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE;2-phenyl-5H-pyrazolo[3,4-c]quinolin-4-one
• CAS NO: 109740-09-2
• Molecular Formula: C₁₆H₁₁N₃O
• Molecular Weight: 261.28
• Mol File: 109740-09-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE(109740-09-2)
• EPA Substance Registry System: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE(109740-09-2)

Safety Data

• Hazardous Substances Data: 109740-09-2(Hazardous Substances Data)

Upstream product

• 51079-10-8 ethyl 2-(1H-indol-3-yl)-2-oxoacetate 
• 100-63-0 phenylhydrazine 
• 508191-77-3 3-phenylsydnone 
• 191171-55-8 2-anilineboronic acid pinacol ester 
• 41658-03-1 ethyl 3-bromoprop-2-ynoate 
• 115316-03-5 ethyl 4-bromo-1-phenyl-1H-pyrazole-3-carboxylate 
• 120-72-9 indole 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 298201-97-5 4-chloro-2-phenyl-2H-pyrazolo[3,4-c]quinoline 
• 298201-68-0 2-phenyl-2H-pyrazolo[3,4-c]quinolin-4-ylamine 

Relevant articles and documents

A novel one-pot synthesis of 2-arylpyrazoloquinolinone derivatives

Two regioisomers of 2-arylpyrazolo[3,4-c]quinolin-4(5H)-ones and 2-arylpyrazolo[4,3-c]quinolin-4(5H)-ones were synthesized by utilizing 3-arylsydnones, ethyl 3-bromopropynoate, and 2-aminophenylboronic acid pinacol ester in presence of catalytic agent Pd(PPh3)4. This efficient one-pot synthesis methodology involved 1,3-dipolar cycloaddition, Suzuki coupling reaction, and intramolecular cyclization three sequence steps.

New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies

This paper reports the study of some 2-arylpyrazolo[3,4-c]quinolin-4-ones, 4-amines, and 4-amino-substituted derivatives designed as human A3 adenosine receptor (AR) antagonists. Most of the herein reported compounds showed a nanomolar affinity

Tricyclic heteroaromatic systems. Pyrazolo[3,4-c]quinolin-4-ones and pyrazolo[3,4-c]quinoline-1,4-diones: Synthesis and benzodiazepine receptor activity

Some pyrazolo[3,4-c]quinoline-4-ones 1-14 and pyrazolo[3,4-c]-quinoline-1,4-diones 15-17 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The moderate binding activity of 1-5, 7, 9-10, 13 is attributable to the lack of the optional proton acceptor at position-1, while the inactivity of the 1,4-dione derivatives 15-17 is due to the lack of the essential proton acceptor at position-3. These conclusions confirm the validity of our proposed pharmacophoric model.