109745-90-6Relevant academic research and scientific papers
Total synthesis of cyclosporine: Access to N-methylated peptides via lsonitrile coupling reactions
Wu, Xiangyang,Stockdill, Jennifer L.,Wang, Ping,Danishefsky, Samuel J.
supporting information; experimental part, p. 4098 - 4100 (2010/05/15)
Recent developments in the use of isonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total synthesis of the important cyclic polypeptide cyclosporine A. Specifically, the disclosed synthetic route demonstrates the utility of microwave-mediated carboxylic acid isonitrile couplings, thioacid isonitrile couplings at ambient temperature, and isonitrile-mediated couplings of carboxylic acids and thioacids with amines to form challenging amide bonds. Copyright
Amino Acids and Peptides, 63. - Peptide Synthesis via N- or O-Activation of Amino Acids with 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarbonitrile. - Synthesis of the 8-11 Tetrapeptide Sequence of Cyclosporin
Schmidt, Ulrich,Potzolli, Bernd
, p. 935 - 942 (2007/10/02)
Peptides and N-methyl peptides have been prepared in high yields and nearly free of racemisation via N-activation (Scheme 1) or O-activation (Scheme 2) of N-acylamino acids and N-acyl-N-methylamino acids, respectively, by 1,2-dihydro-4,6-dimethyl-2-thioxo
