109745-93-9

Upstream product

• 21760-98-5 L-valine benzyl ester 
• 100-52-7 benzaldehyde 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 

Downstream Products

• 81135-38-8 benzyl (2S)-3-methyl-2-(methylamino)butanoate 
• 258826-44-7 (S)-2-Benzylamino-3-methyl-butyric acid benzyl ester 
• 200063-54-3 (S)-2-(Acetyl-benzyl-amino)-3-methyl-butyric acid 
• 200063-57-6 (S)-2-(Acetyl-benzyl-amino)-3-methyl-butyric acid benzyl ester 
• 109745-91-7 (S)-2-[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-methyl-amino]-3-methyl-butyric acid benzyl ester 
• 89536-99-2 benzyl (S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)-N,4-dimethylpentanamido)-3-methylbutanoate 
• 109745-90-6 Boc-Leu-MeVal-OBn 
• 109745-82-6 (S)-2-[(3-Cyano-4,6-dimethyl-pyridin-2-ylsulfanyl)-methyl-amino]-3-methyl-butyric acid benzyl ester 

Relevant academic research and scientific papers

Novel formation and crystal structure of 2-(2,2,2-trifluoroethylidene)-6-trifluoro-methyl-2,3-dihydro-4H-1,4-oxazin-3- ones from N-acetyl-N-alkyl-α-amino acids

The title compounds (2a-g) were formed from N-acetyl-N-alkyl-α-amino acids (1a-g) on treatment with trifluoroacetic anhydride in the presence of pyridine. The structure of the product (2a) was determined by single crystal X-Ray analysis.

Amino Acids and Peptides, 63. - Peptide Synthesis via N- or O-Activation of Amino Acids with 1,2-Dihydro-4,6-dimethyl-2-thioxo-3-pyridinecarbonitrile. - Synthesis of the 8-11 Tetrapeptide Sequence of Cyclosporin

Peptides and N-methyl peptides have been prepared in high yields and nearly free of racemisation via N-activation (Scheme 1) or O-activation (Scheme 2) of N-acylamino acids and N-acyl-N-methylamino acids, respectively, by 1,2-dihydro-4,6-dimethyl-2-thioxo