109757-62-2 Usage
Structure
A derivative of benzene with two bromine atoms attached to the benzene ring and a butyl chain with a bromine substituent attached to the third position.
Organic synthesis
Used as a building block for the synthesis of various organic compounds.
Chemical research
Employed in the development of new chemical methods and techniques.
Pharmaceutical production
Serves as an intermediate in the production of pharmaceuticals.
Agrochemical production
Utilized in the synthesis of agrochemicals.
Fine chemicals production
Acts as an intermediate in the production of fine chemicals.
Nucleophilic substitution
Can undergo nucleophilic substitution reactions.
Palladium-catalyzed cross-coupling
Can participate in palladium-catalyzed cross-coupling reactions.
Flammability
It is flammable and should be handled with care.
Harmful if swallowed or inhaled
It poses a risk if ingested or inhaled.
Skin and eye irritation
May cause skin and eye irritation upon contact.
Safety precautions
Should be handled and used with care, following proper safety protocols and guidelines.
Check Digit Verification of cas no
The CAS Registry Mumber 109757-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,7,5 and 7 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 109757-62:
(8*1)+(7*0)+(6*9)+(5*7)+(4*5)+(3*7)+(2*6)+(1*2)=152
152 % 10 = 2
So 109757-62-2 is a valid CAS Registry Number.
109757-62-2Relevant academic research and scientific papers
A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups
Peters, Martin,Trobe, Melanie,Tan, Hao,Kleineweischede, Rolf,Breinbauer, Rolf
supporting information, p. 2442 - 2449 (2013/04/24)
Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route and the halogen/triflate route, two strategies have successfully been established. The synthesis of core building blocks with aliphatic (Ala, Val, Leu, Ile), aromatic (Phe), polar (Cys, Lys), hydrophilic (Ser, Gln), and acidic (Glu) amino acid side chains are reported. Turn on: Teraryl-based α-helix mimetics can be effectively produced by sequential Suzuki coupling of a central core fragment featuring electronically differentiated leaving groups with aryl boronic pinacol esters (see scheme; dppf=1,1′-bis(diphenylphosphino) ferrocene, DME=dimethoxyethane, Pin=pinacol, Tf=trifluoromethanesulfonyl). With a set of only 2×18 building blocks, all permutations of α-helix mimetics can be produced. Copyright
