218153-01-6

Basic information

• Product Name: Benzenebutanol, 3-bromo-
• CAS NO: 218153-01-6
• Molecular Formula: C10H13BrO
• Molecular Weight: 229.117
• Mol File: 218153-01-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenebutanol, 3-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanol, 3-bromo-(218153-01-6)
• EPA Substance Registry System: Benzenebutanol, 3-bromo-(218153-01-6)

Safety Data

• Hazardous Substances Data: 218153-01-6(Hazardous Substances Data)

Upstream product

• 54887-20-6 1-bromo-3-n-butylbenzene 
• 161173-98-4 1-bromo-3-(but-3-en-1-yl)benzene 
• 823-78-9 meta-bromobenzyl bromide 
• 899350-32-4 4-(3-bromophenyl)-butyric acid 
• 3132-99-8 m-bromobenzoic aldehyde 
• 6399-81-1 triphenylphosphine hydrobromide 

Downstream Products

• 109757-62-2 1-bromo-3-(4-bromobutyl)benzene 
• 1426943-39-6 2-(4-(3-bromophenyl)butyl)isoindoline-1,3-dione 
• 931430-07-8 Toluene-4-sulfonic acid 4-(3-bromo-phenyl)butyl ester 
• 853643-74-0 1-bromo-3-(4-methoxy-butyl)-benzene 
• 620600-91-1 [4-(3-bromophenyl)butoxy](tert-butyl)diphenylsilane 

Relevant articles and documents

Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation

The enantioselective amination of C(sp3)-H bonds is a powerful synthetic transformation yet highly challenging to achieve in an intermolecular sense. We have developed a family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which we have associated chiral cations derived from quaternized cinchona alkaloids. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates bearing pendant hydroxyl groups. Additionally, the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of product versus Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.

A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics. Central to our strategy is the use of a benzene core unit featuring two leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for terphenyl assembly. With the halogen/diazonium route and the halogen/triflate route, two strategies have successfully been established. The synthesis of core building blocks with aliphatic (Ala, Val, Leu, Ile), aromatic (Phe), polar (Cys, Lys), hydrophilic (Ser, Gln), and acidic (Glu) amino acid side chains are reported. Turn on: Teraryl-based α-helix mimetics can be effectively produced by sequential Suzuki coupling of a central core fragment featuring electronically differentiated leaving groups with aryl boronic pinacol esters (see scheme; dppf=1,1′-bis(diphenylphosphino) ferrocene, DME=dimethoxyethane, Pin=pinacol, Tf=trifluoromethanesulfonyl). With a set of only 2×18 building blocks, all permutations of α-helix mimetics can be produced. Copyright

AMINO-5-[4-(DIFLUOROMETHOXY)-PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE

The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.