1097958-75-2

Upstream product

• 100-39-0 benzyl bromide 
• 1217-89-6 1-benzylisatin 
• 106-40-1 4-bromo-aniline 
• 91-56-5 indole-2,3-dione 

Downstream Products

• 1097958-93-4 (Z)-1-benzyl-4-(4-bromophenylimino)-1,4-dihydro-2H-3,1-benzoxazin-2-one 
• 1598427-56-5 1-benzyl-3-(hydroxymethyl)-3-((4-bromophenyl)amino)indolin-2-one 
• 1598436-43-1 tetramethyl 1-benzyl-1′-(4-bromophenyl)-2-oxo-1′H-spiro-[indoline-3,2′-pyridine]-3′,4′,5′,6′-tetracarboxylate 

Relevant academic research and scientific papers

α-Selective Allylation of Isatin Imines Using Metallic Barium

The Barbier-type allylation of isatin imines with allylic chlorides was achieved by using metallic barium as the promoter. Various α-allylated 3-amino-2-oxindoles were synthesized from the corresponding allylic chlorides and isatin imines. The double-bond geometry of allylic chlorides was retained throughout the reaction. An arylic bromide or iodide functionality of the products was robust to metalation under the optimum reaction conditions.