1097958-75-2Relevant articles and documents
α-Selective Allylation of Isatin Imines Using Metallic Barium
Yanagisawa, Akira,Yamafuji, Seiya,Sawae, Toshiki
, p. 2019 - 2023 (2016)
The Barbier-type allylation of isatin imines with allylic chlorides was achieved by using metallic barium as the promoter. Various α-allylated 3-amino-2-oxindoles were synthesized from the corresponding allylic chlorides and isatin imines. The double-bond geometry of allylic chlorides was retained throughout the reaction. An arylic bromide or iodide functionality of the products was robust to metalation under the optimum reaction conditions.