1098108-56-5

Basic information

• Product Name: (S)-2-bromo-1-(3-bromophenyl)ethanol
• Synonyms: (S)-2-bromo-1-(3-bromophenyl)ethanol
• CAS NO: 1098108-56-5
• Molecular Weight: 279.959
• Mol File: 1098108-56-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-2-bromo-1-(3-bromophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-bromo-1-(3-bromophenyl)ethanol(1098108-56-5)
• EPA Substance Registry System: (S)-2-bromo-1-(3-bromophenyl)ethanol(1098108-56-5)

Safety Data

• Hazardous Substances Data: 1098108-56-5(Hazardous Substances Data)

Usage

General Description

(S)-2-bromo-1-(3-bromophenyl)ethanol, also known as α-bromo-α-(3-bromophenyl)ethanol or alpha-bromo-alpha-(3-bromophenyl)ethanol, is a chiral compound with the molecular formula C8H8Br2O. It is a colorless to pale yellow liquid with a faint odor, and is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. As a chiral molecule, it has two enantiomers, (R)-2-bromo-1-(3-bromophenyl)ethanol and (S)-2-bromo-1-(3-bromophenyl)ethanol, and is used in various chemical processes and research applications. It is important to handle this compound with care, as it is toxic and can cause skin and eye irritation, and should be handled in a well-ventilated area with appropriate personal protective equipment.

Upstream product

• 28229-69-8 2-(3-bromophenyl)ethan-1-ol 
• 40422-70-6 1-bromo-3-(2-bromoethyl)benzene 
• 18523-22-3 2,3'-dibromoacetophenone 

Downstream Products

• 131567-05-0 (S)-(+)-2-(3-bromophenyl)oxirane 
• 1158540-96-5 (S)-(+)-1-(3-bromo-phenyl)-2-phenoxy-ethanol 
• 740078-36-8 (S)-2-amino-1-(3-bromophenyl)ethanol 
• 380610-92-4 (R)-tert-butyl [1-(3-bromophenyl)-2-hydroxyethyl]carbamate 
• 209963-04-2 (R)-2-amino-2-(3-bromophenyl)ethanol 

Relevant articles and documents

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%).

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water

A practical and convenient method for the efficient and regio- and stereoselective ring-opening of enantiopure monosubstituted epoxides by sodium azide under hydrolytic conditions is reported. The ring-opening of enantiopure styryl and pyridyl (S)-epoxides by N3- in hot water takes place preferentially at the internal position with complete inversion of configuration to produce (R)-2-azido ethanols with up to 99% enantio- and regioselectivity, while the (S)-adamantyl oxirane provides mainly the (S)-1-adamantyl-2-azido ethanol in excellent yield. In general, 1,2-amino ethanols were obtained in high yield and excellent enantiopurity by the reduction of the chiral 1,2-azido ethanols with PPh3 in water/THF, and then converted into the Boc or acetamide derivatives.