109822-72-2

Upstream product

• 288-32-4 1H-imidazole 
• 90-02-8 salicylaldehyde 
• 56-40-6 glycine 
• 6343-78-8 N-salicylideneglycine 
• 6046-93-1 copper(II) acetate monohydrate 

Relevant academic research and scientific papers

One-dimensional chain copper(II) and nickel(II) coordination polymers with N-salicylideneglycine schiff base ligand

[Cu(Sal-Gly)(Im)(H2O)] (1) and [Ni(Sal-Gly)(H2O) 2] (2) (Sal- Gly = N-salicylideneglycinate) was synthesized and structurally characterized. 1 and 2 are one-dimensional chain coordination polymers. In 1, Cu(II) ion has a five-coordinated square-pyramidal geometry and is surrounded by two O and one N atoms from a tetradentate Sal-Gly dianion and one N atom from imidazole ligand and one O from adjacent Sal-Gly ligand. In 2, Ni(II) adopts six-coordinated distorted octahedral geometry and is surrounded by two O and one N atoms from a tetradentate Sal-Gly dianion, two O from two aqua ligands, and one O from adjacent Sal-Gly ligand.

Synthesis, structure, and antimicrobial activity of copper(II) chelates containing imidazole and condensation products of α-amino acids with salicylaldehyde and its derivatives

Salicylaldehyde, 5-bromo- and 5-nitrosalicylaldehydes, 2- hydroxynaphthalene-1-carbaldehyde, and 2,3-, 2,4-, and 2,5- dihydroxybenzaldehydes reacted with glycine, alanine, and phenylalanine in ethanol in the presence of imidazole (Im) and copper(II) acetate hydrate to give copper(II) chelates with the composition Cu(Im)(L) · nH2O (H2L is the condensation product of the above aldehydes with α-amino acids; n = 0-2). The structure of the complex Cu(Im)(L 1) [H2L1 = 2-(2-hydroxybenzylideneamino)acetic acid] was determined by X-ray analysis. The crystalline structure of [2-(2-hydroxybenzylideneamino)acetato](imidazole)copper is formed by polymeric chains of the Cu(Im)(L1) molecules linked through bridging oxygen atoms in the carboxy groups of the Schiff base ligand. The coordination unit has a distorted tetragonal pyramid configuration, where the pyramid base is composed of the phenol and carboxy oxygen atoms, CH=N nitrogen atom in the ligand H2L1 and imidazole nitrogen atom. The oxygen atom in the carboxy group in the neighboring molecule occupies the apical position of the coordination pyramid. The other coordination compounds also have polynuclear structure with the Schiff base H2L acting as doubly deprotonated tridentate O,N,O-ligand and bridging carboxy groups. Thermal decomposition of the complexes includes their dehydration (70-95 C), while complete thermal decomposition occurs at 360-530 C. The synthesized complexes showed selective antimicrobial activity in the concentration range from 75 to 300 μg/ml against a number of standard strains of Staphylococcus aureus and Escherichia coli.