109830-72-0Relevant academic research and scientific papers
Synthesis of substituted pyrido[3′,2′:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones and their sulfinyl and sulfonyl derivatives
Kalugin,Shestopalov
, p. 523 - 530 (2017/09/15)
A method for the synthesis of previously unknown pyrido[3′,2′:4,5]thieno[3,2-c]isoquinolin-5(6H)-ones was suggested, which includes a condensation reaction of substituted 3-cyanopyridine-2(1H)-thiones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation products with potassium tert-butoxide. The oxidation of the condensation products to sulfoxides or sulfones and subsequent treatment of these compounds with potassium tert-butoxide led to substituted pyrido[3′,2′:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11-oxides or substituted pyrido[3′,2′:4,5]thieno[3,2-c]isoquinolin-5(6H)-one 11,11-dioxides.
[5C + 1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: A synthetic route to multi-substituted 2-aminopyridines
Xin, Xiaoqing,Huang, Peng,Xiang, Dexuan,Zhang, Rui,Zhao, Fengyu,Zhang, Ning,Dong, Dewen
, p. 1001 - 1006 (2013/02/26)
A facile and efficient synthetic route to multi-substituted 2-aminopyridines has been developed via a formal [5C + 1N] annulation of readily available 2,4-pentadienenitriles with hydroxylamine (NH2OH) under very mild conditions, which involves
Phosphine-catalyzed annulations between modified allylic derivatives and polar dienes and substituent effect on the annulation mode
Tian, Junjun,Sun, Haiyun,Zhou, Rong,He, Zhengjie
supporting information, p. 1348 - 1351 (2013/11/06)
In this work, the phosphine-catalyzed annulation reactions between modified allylic derivatives and polar 1,1-dicyano-1,3-dienes have been studied. In the catalysis of PPh3 (20 mol%), a [4+1] annulation reaction is realized between a series of 1,1-dicyano-2,4-diaryl-1,3-dienes and ethoxycarbonyl- activated allylic acetate, producing polysubstituted cyclopentenes in modest to excellent yields. It is also observed that the substituents of both 1,3-dienes and allylic derivatives have a significant influence on the annulation mode: under the catalysis of PPh3 or PBu3 (20 mol%), regioselective [3+2] annulation products are formed from differently substituted substrates. Chemoselective phosphine-catalyzed [4+1] and [3+2] annulations of modified allylic derivatives and polar 1,3-dienes have been realized, and substituent effect on the annulation mode was first observed. Copyright
