64792-49-0

Basic information

• Product Name: Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate
• CAS NO: 64792-49-0
• Molecular Weight: 223.272
• Mol File: 64792-49-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate(64792-49-0)
• EPA Substance Registry System: Ethyl (2,2-dimethyl-4-tetrahydropyranylidene)cyanoacetate(64792-49-0)

Safety Data

• Hazardous Substances Data: 64792-49-0(Hazardous Substances Data)

Upstream product

• 1194-16-7 2,2-dimethyltetrahydropyran-4-one 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 120729-51-3 ethyl <2,2-dimethyl-4-(o-tolyl)-4-tetrahydropyranyl>cyanacetate 
• 1313602-75-3 N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methoxy-4-methylaniline 
• 1313602-71-9 3-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline 
• 1313602-72-0 4-tert-butyl-N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]aniline 
• 1313602-73-1 N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-3-methoxyaniline 
• 1313603-03-0 3-{[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino}-N,N-dimethylbenzenesulfonamide 
• 1313603-04-1 N-(3-{[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]amino}phenyl)acetamide 
• 337486-01-8 C₁₆H₂₅NO 
• 400748-66-5 C₁₆H₂₅NO₂ 
• 1279867-05-8 C₁₅H₂₂ClNO 
• 1313602-74-2 N-[2-(2,2-dimethyl-4-phenyltetrahydro-2H-pyran-4-yl)ethyl]-4-methoxyaniline 
• 1313603-44-9 C₁₅H₂₂ClNO 
• 368837-34-7 2-(4-(4-fluorophenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl)ethanamine 
• 1313603-45-0 2-(4-(3-fluorophenyl)-2,2-dimethyltetrahydro-2H-pyran-4-yl)ethanamine 

Relevant articles and documents

Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT)

A series of tetrahydropyranyl (THP) derivatives has been developed as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) for use as anticancer agents. Structural modification of the submicromolar hit compound 3 led to the potent 3-methoxy substituted analogue 27. Further SAR development around the THP ring resulted in an additional 10-fold increase in potency, exemplified by analogue 75 with an IC50 of 1.3 nM. Active and potent compounds demonstrated a dose-dependent increase in Ras cytosolic protein. Potent ICMT inhibitors also reduced cell viability in several cancer cell lines with growth inhibition (GI50) values ranging from 0.3 to >100 μM. However, none of the cellular effects observed using ICMT inhibitors were as pronounced as those resulting from a farnesyltransferase inhibitor.