109923-78-6Relevant articles and documents
L-ribonucileosides for racemic RNA
Moyroud,Botta,Strazewski
, p. 693 - 695 (1999)
Two L-ribosyl donors were synthesised from L-xylose, then submitted to a glycosidation reaction according to Vorbruggen's conditions to furnish L- ribonucleosides in high yield.
Chirally-modified oligonucleotides and the control of gene expression. The case of L-DNAs and -RNAs
Garbesi, Anna,Capobianco, Massimo L.,Colonna, Francesco P.,Maffini, Mauro,Niccolai, Daniela,Tondelli, Luisa
, p. 1275 - 1287 (2007/10/03)
The affinity of L-DNAs, L-RNAs and LD-DNAs for homopurine · homopyrimidine d.s. D-DNA and s.s. D-RNA was probed by gel electrophoresis and CD spectroscopy. It was found that the L-modified oligomers do not bind to d.s. DNA and to natural RNA that contains all four natural bases. Thus they cannot be used, in general, for the control of gene expression according to the antigene and antisense methodologies. Heterochiral complexes with 1:1 stoichiometry and low hem stability are formed, instead, by homopurinic L- RNA or L/D-DNA and homopyrimidinic L-RNA with the W/C complementary natural RNA sequences.
Studies on deoxynucleic acids and related compounds. IV. Syntheses of an octanucleotide containing a recognition site for restriction enzyme Eco RI and of an arabinosyladenine analog
Ohtsuka,Morisawa,Ikehara
, p. 874 - 880 (2007/10/02)
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