1099653-07-2Relevant academic research and scientific papers
Direct α-alkylation of ketones with primary alcohols catalyzed by iridium-CNP complex
Wang, Dawei,Zhao, Keyan,Ma, Piming,Xu, Chongying,Ding, Yuqiang
, p. 7233 - 7235 (2014)
The α-alkylation of ketones with primary alcohols was realized by CC cross-coupling with iridium-CNP complexes as catalyst. This reaction proceeds via dehydrogenation reactions, aldol condensation, and hydrogenation using the borrowed hydrogen atoms from alcohols. The pyridyl methanols and other heterocyclic substituted methanols, especially alkyl alcohols, were also suitable for this transformation.
Iridium-CNP complex catalyzed cross-coupling of primary alcohols and secondary alcohols by a borrowing hydrogen strategy
Wang, Dawei,Zhao, Keyan,Yu, Xin,Miao, Hongyan,Ding, Yuqiang
, p. 42924 - 42929 (2015/02/19)
A highly efficient C-C bond formation has been developed through the cross-coupling of primary and secondary alcohols. The corresponding functionalized ketones were obtained with an iridium-CNP complex as a catalyst through the borrowing hydrogen strategy. The present methodology provides an easy alternative method to aldol reaction derivatives. More importantly, the complexes were also effective catalysts for the alkylation of an aromatic amine with a tertiary alkyl amine. This journal is
Efficient ruthenium-catalyzed α-alkylation of ketones using pyridyl methanols
Yan, Feng-Xia,Zhang, Min,Wang, Xiao-Ting,Xie, Feng,Chen, Meng-Meng,Jiang, Huanfeng
supporting information, p. 1193 - 1198 (2014/02/14)
By employing an easily available [Ru(p-cymene)Cl2] 2/Xantphos/t-BuOK catalyst system, the α-alkylation of ketones was demonstrated by using pyridyl methanol as the alkylating reagents. The synthetic protocol allows synthesizing a wid
