1099751-95-7

Upstream product

• 91202-69-6 (Z)-4-(tert-butyldimethylsilyloxy)but-2-en-1-ol 
• 163976-62-3 [(Z)-4-[(tert-butyldimethylsilyl)oxy]-2-buten-1-yl] ethyl carbonate 
• 1099751-57-1 (2E)-4-(tert-butyldimethylsiloxy)but-2-enyl methyl carbonate 
• 100-46-9 benzylamine 

Downstream Products

• 1599422-97-5 N-(fluorenylmethoxycarbonyl)glycine-{N-benzyl-N-[4-tert-butyldimethylsilyloxy-(2E)-buten-1-yl]}amide 
• 1599422-98-6 N-(trifluoroacetyl)glycine {N-benzyl-N-[4-tert-butyldimethylsilyloxy-(2E)-buten-1-yl]}amide 
• 1599423-04-7 N-(trifluoroacetyl)glycine {N-benzyl-N-[4-hydroxy-(2E)-buten-1-yl]}amide 
• 1599423-06-9 N-(tert-butyloxycarbonyl)glycine {N-benzyl-N-[4-hydroxy-(2E)-buten-1-yl]}amide 
• 1599423-07-0 N-(tert-butyloxycarbonyl)-β-alanine {N-benzyl-N-[4-hydroxy-(2E)-buten-1-yl]}amide 
• 1599423-08-1 N-(tert-butyloxycarbonyl)sarcosine {N-benzyl-N-[4-hydroxy-(2E)-buten-1-yl]}amide 
• 1599423-12-7 N-(trifluoroacetyl)glycine {N-benzyl-N-[4-ethoxycarbonyloxy-(2E)-buten-1-yl]}amide 
• 1599423-13-8 N-(tert-butyloxycarbonyl)glycine {N-benzyl-N-[4-ethoxycarbonyl-oxy-(2E)-buten-1-yl]}amide 
• 1599423-14-9 N-(tert-butyloxycarbonyl)-β-alanine {N-benzyl-N-[4-ethoxycarbonyl-oxy-(2E)-buten-1-yl]}amide 
• 1599423-15-0 N-(tert-butyloxycarbonyl)sarcosine {N-benzyl-N-[4-ethoxycarbonyl-oxy-(2E)-buten-1-yl]}amide 
• 1599423-21-8 N-(tert-butyloxycarbonyl)sarcosine {N-[4-benzoyloxy-(2E)-buten-1-yl]-N-benzyl}amide 
• 1599423-19-4 1-benzyl-4-trifluoracetyl-5-vinylpiperazin-2-one 
• 1599423-20-7 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one 
• 1599423-22-9 N-(tert-butyloxycarbonyl)-α-deuterio-sarcosine {N-benzyl-N-[4-ethoxy-carbonyloxy-(2E)-buten-1-yl]}amide 

Relevant academic research and scientific papers

Synthesis of α-Amino-γ-lactams through Pd-Catalzed Intramolecular Allylic Alkylation of Sarcosine Allyl Amides

N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed.

Synthesis of α-amino-γ-lactams through Pd-catalzed intramolecular allylic alkylation of sarcosine allyl amides

N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed. Copyright

Enantioselective iridium-catalyzed allylic aminations of allylic carbonates with functionalized side chains. Asymmetric total synthesis of (S)-vigabatrin

Indium-catalyzed aminations of allylic carbonates containing a variety of O-functional groups have been explored. High degrees of regio- as well as enantioselectivity were achieved with diacylamides under salt-free conditions and with arylamines. The results allowed the antiepilepsy drug (5)-vigabatrin to be prepared via a very short route.