1599423-20-7

Basic information

• Product Name: 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one
• Synonyms: 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one
• CAS NO: 1599423-20-7
• Molecular Weight: 316.4
• Mol File: 1599423-20-7.mol

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one(1599423-20-7)
• EPA Substance Registry System: 1-benzyl-4-tert-butyloxycarbonyl-5-vinylpiperazin-2-one(1599423-20-7)

Safety Data

• Hazardous Substances Data: 1599423-20-7(Hazardous Substances Data)

Upstream product

• 1099751-95-7 (2E)-N-benzyl-4-(tert-butyldimethylsiloxy)but-2-en-1-amine 
• 1599423-13-8 N-(tert-butyloxycarbonyl)glycine {N-benzyl-N-[4-ethoxycarbonyl-oxy-(2E)-buten-1-yl]}amide 
• 1599423-06-9 N-(tert-butyloxycarbonyl)glycine {N-benzyl-N-[4-hydroxy-(2E)-buten-1-yl]}amide 
• 1599422-99-7 N-(tert-butyloxycarbonyl)glycine {N-benzyl-N-[4-tert-butyldimethylsilyloxy-(2E)-buten-1-yl]}amide 

Relevant articles and documents

Synthesis of α-Amino-γ-lactams through Pd-Catalzed Intramolecular Allylic Alkylation of Sarcosine Allyl Amides

N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed.

Synthesis of α-amino-γ-lactams through Pd-catalzed intramolecular allylic alkylation of sarcosine allyl amides

N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed. Copyright