1599423-13-8Relevant articles and documents
Synthesis of α-Amino-γ-lactams through Pd-Catalzed Intramolecular Allylic Alkylation of Sarcosine Allyl Amides
Thies, Sarah,Kazmaier, Uli
, p. 1695 - 1707 (2015/10/05)
N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed.
Synthesis of α-amino-γ-lactams through Pd-catalzed intramolecular allylic alkylation of sarcosine allyl amides
Thies, Sarah,Kazmaier, Uli
, p. 1695 - 1707 (2014/03/21)
N-Protected amino acid allyl amides with an allylic leaving group can be used as substrates in palladium-catalyzed allylic alkylation. Whereas intermolecular allylations proceed with excellent yields under standard conditions for enolate reactions, the intramolecular version is not a trivial issue. N-Protected glycine amides preferentially form piperidinones through N-allylation, but the corresponding sarcosine derivatives provide γ-lactams in acceptable to good yields in dichloromethane, especially when the corresponding titanium enolates are formed. Copyright