109984-82-9Relevant articles and documents
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Wolff
, p. 1623 (1945)
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1,2:5,6-di-O-isopropylidene-α-D-glucofuranose and 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose as chiral auxiliaries in Michael and aldol addition reactions
Pinheiro, Sergio,Pedraza, Sergio F.,Peralta, Monica A.,Carvalho, Erika M.,Farias, Florence M.C.,Ferreira, Vitor F.
, p. 901 - 913 (2007/10/03)
The asymmetric Michael and aldol addition reactions of chiral esters derived from DIPGF(1) and DIPFP(2) were studied. The best diastereoselectivity (60% d.e.) was obtained for the conjugate addition of n-BuCu?BF3 to the crotonate derivative of 1 at low temperature (-78 °C), leading to the corresponding R-adduct. Under this condition compound 2 is a less efficient chiral auxiliary. The lower stereoselectivities (10% d.e.) in aldol reactions from butyrate derivatives of 1 and 2 and cyclohexanone are attributed to mixtures of E and Z-enolates in the kinetic deprotonation step.
Synthesis, toxicology and pharmacokinetics of butyric esters
Pouillart, Philippe,Ronco, Gino,Pieri, Francois,Brazier, Michel,Villa, Pierre
, p. 471 - 474 (2007/10/02)
Synthesis of four glucose and galactose mono- and poly- butyric esters was carried out.A preliminary toxicologic and pharmacokinetic study showed that it was possible to utilise these new molecules and allows an estimation to be made of their seric half-life in animals.The results obtained show it is possible to maintain large seric potential n-butyric acid concentrations.The first tests performed on experimental animals with tumors treated by these esters show a survival increase similar to that with butyric salts. n-butyric acid/butyric ester/glucose ester/galactose ester/prolonged effect