125161-47-9

Usage

InChI:InChI=1/C13H22O7/c1-4-5-8(16)17-10-9(7(15)6-14)18-12-11(10)19-13(2,3)20-12/h7,9-12,14-15H,4-6H2,1-3H3/t7-,9-,10+,11-,12-/m1/s1

Upstream product

• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 109984-82-9 O³-butyryl-O¹,O²;O⁵,O⁶-diisopropylidene-α-D-glucofuranose 

Downstream Products

• 70834-19-4 5,6-O-isopropylidene-D-glucofuranose 
• 125161-48-0 6-O-Butanoyl-1,2-O-isopropylidene-α-D-glucofuranose 

Relevant academic research and scientific papers

Induction of erythroid differentiation of human K562 cells by 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives.

In this paper we report the synthesis of twelve 3-O-acyl-1,2-O-isopropylidene-D-glucofuranose derivatives and the results obtained on their effects in inducing erythroid differentiation of human leukemic K562 cells. The data obtained demonstrate that two of the newly synthetized compounds are able to induce erythroid differentiation of K562 cells. In addition, these same compounds potentiate K562 erythroid differentiation induced by cytosine arabinoside, retinoic acid and mithramycin. Inducers of erythroid differentiation stimulating fetal gamma-globin synthesis could be considered for possible use in the experimental therapy of hematological diseases associated with a failure in the expression of adult beta-globin genes.

SYNTHESIS OF MONOESTERS AS SURFACTANTS AND DRUGS FROM D-GLUCOSE

We have synthesized a series of monoesters from D-glucose corresponding to the structures 3-O-acyl, 6-O-acyl-1,2-O-isopropylidene-α-D-glucofuranose and 3-acyl-D-glucose, following the sequence of reactions : D-glucose -> diacetone glucose -> acylation -> partial or total deprotection.These compounds were prepared as either potential non-ionic surfactants (fatty acid esters and perfluoroalkylated ester) or antitumour drugs (n-butyric esters).Results concerning surface activity, toxicity and antitumour effects are reported.A novel method for obtaining partially deprotected 6-O-acyl esters from their corresponding 3-O-acyl isomers is reported.Deprotection conditions have been studied and a higher selectivity in partial deprotection has been achieved.We have given particular attention to the choice of solvents and reagents in order not to limit the extent to which the products might be applied.