109988-59-2

Upstream product

• 2346-26-1 2,4-oxazolidinedione 
• 97580-26-2 2-(1-4'-methoxyphenylethenyl)-5-hexen-1-ol 
• 97580-22-8 ethyl 2-(1-4'-methoxyphenylethenyl)-5-hexenoate 
• 7706-82-3 (E)-ethyl 3-(4-methoxyphenyl)but-2-enoate 

Downstream Products

• 109988-63-8 N-<2-(1-4'-methoxyphenylethenyl)-5-hexenyl>-4-phenylthiooxazolidin-2-one 
• 109988-67-2 5,5a,6,7,8,8a,9,9a-octahydro-8a-(4-methoxyphenyl)-8-methyl-1H,3H-oxazolo<3,4-a>cyclopentapyridin-3-one 
• 120402-10-0 4-Hydroxy-3-{2-[1-(4-methoxy-phenyl)-vinyl]-hex-5-enyl}-oxazolidin-2-one 

Relevant academic research and scientific papers

A Highly Diastereoselective Synthesis of cis-4a-Aryloctahydro-cyclopentapyridine Derivatives through Tandem Radical Cyclization of α-amino Radical Polyene Species

8a-Aryloxazolocyclopentapyridines (9a-c) were prepared via a route involving radical cyclization of α-acylamino radical polyene species generated by treatment of 4-phenylthiooxazolidin-2-ones (8a-c) with tri-n-butyltin hydride in the presence of azobisisobutyronitrile (AIBN).Conversion of 9a to cis-octahydro-2,5-dimethyl-4a-phenylcyclopentapyridine (19) was successfully achieved via a route involving ring cleavage of the oxazolidinone ring of 9a, oxidation of hydroxymethyl group, and decarbonylation.Keywords - radical cyclization; cyclopentapyridine; α-acylamino radical; α-amino radical-polyene; tandem radical cyclization; decarbonylation

Effect of A-Strain on a Synthesis of cis-Fused 4a-Aryloctahydro-1H-cyclopentapyridine Derivatives through Tandem Radical Cyclisation of an α-Acylamino-Polyene System

An efficient synthesis of the cis-fused 4a-aryloctahydro-1H-cyclopentapyridine ring system, an analogue of 4a-aryldecahydroisoquinoline, was achieved through a tandem radical approach by cyclisation of free radical-polyene species.