110023-85-3Relevant academic research and scientific papers
A convenient synthesis of deuterium labeled amines and nitrogen heterocycles with KOt-Bu/DMSO-d6
Hu, Yu,Liang, Liang,Wei, Wen-Tao,Sun, Xiang,Zhang, Xue-Jing,Yan, Ming
, p. 1425 - 1430 (2015/02/19)
H/D exchanges of arylmethyl amines and nitrogen heterocycles were conveniently achieved with KOt-Bu/DMSO-d6. The method is also applicable for phenyl benzyl ethers, diarylmethanes, and alkyl arenes. These H/D exchange reactions are suggested to
A convenient and general reduction of amides to amines with low-valent titanium
Zhang, Tongxin,Zhang, Yan,Zhang, Weixi,Luo, Meiming
supporting information, p. 2775 - 2780 (2014/03/21)
Low-valent titanium readily prepared in situ from TiCl4 and Mg powder in THF is found to be an active agent for the reduction of amides which were previously considered to be inert towards low-valent titanium. The reaction proceeds under very mild conditions, and is applicable to all types of amides, primary, secondary and tertiary, to produce the corresponding amines in good to excellent yields. This new finding provides a practical, convenient and general method for the important transformation of amides to amines. A plausible reaction mechanism is proposed.
REACTION OF TRANSITION METAL CARBONYLS WITH HETEROCYCLIC SYSTEMS. VI. THE INTERACTION OF Fe2(CO)9 WITH N-BENZYLOXYPIPERIDINE AND RELATED COMPOUNDS
Blum, Y.,Becker, Y.,Shvo, Y.
, p. 65 - 76 (2007/10/02)
N-Benzyloxypiperidine exhibits an unexpected type of reactivity toward Fe2(CO)9.Benzaldehyde and N-formylpiperidine are formed, most probably in a concerted manner, as revealed by deuterium-labeling experiments.Several mechanistic details of this reaction have been elucidated.The nature of the reaction contrasts with that of N-propyloxy-N-methylaniline, which upon treatment with Fe2(CO)9 undergoes insertion of a CO group into the N-O bond to generate a carbamate.
