11005-63-3

Basic information

• Product Name: K-STROPHANTHIN
• Synonyms: STROPHANTHIN K;combetin;eustrophinum;kombe-strophanthin;K-STROPHANTHIN;strophantin-K;Strophantin K (Mixture)
• CAS NO: 11005-63-3
• Molecular Formula: C36H54O14
• Molecular Weight: 710.81
• EINECS: 234-239-9
• Mol File: 11005-63-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 165 °C
• Boiling Point: 877.1°C at 760 mmHg
• Flash Point: 270.1°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.613
• Water Solubility: 22.73g/L(25 oC)
• CAS DataBase Reference: K-STROPHANTHIN(CAS DataBase Reference)
• NIST Chemistry Reference: K-STROPHANTHIN(11005-63-3)
• EPA Substance Registry System: K-STROPHANTHIN(11005-63-3)

Safety Data

• Hazard Codes: T
• Statements: 23/25-33
• Safety Statements: 45
• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 11005-63-3(Hazardous Substances Data)

Usage

Description

K-STROPHANTHIN, also known as strophanthin, is a cardiac glycoside derived from the seeds of the plant Strophanthus gratus. It is characterized by its ability to inhibit the sodium-potassium pump in heart muscle cells, which results in an increase in the force of contractions and improved heart efficiency. K-STROPHANTHIN is traditionally used in medicine for treating heart conditions such as heart failure and is under investigation for its potential anti-cancer properties. Due to its potency, K-STROPHANTHIN requires careful administration under the supervision of a healthcare professional to avoid toxic effects.

Uses

Used in Cardiac Medicine:
K-STROPHANTHIN is used as a cardiac stimulant for treating heart conditions such as heart failure. Its application is based on its ability to enhance the force of heart muscle contractions, thereby improving the heart's efficiency in pumping blood.
Used in Pharmaceutical Research:
K-STROPHANTHIN is used as a subject of research for its potential anti-cancer properties. Studies are exploring how this compound may be utilized in the development of treatments for various types of cancer, leveraging its biological activities to target and inhibit cancer cell growth.
Used in Drug Formulation:
K-STROPHANTHIN is used as an active pharmaceutical ingredient in the formulation of medications aimed at managing heart failure. Its inclusion in these formulations is due to its proven efficacy in strengthening cardiac contractions, which is crucial for the treatment of this condition.

InChI:InChI=1/C36H54O14/c1-18-31(50-32-30(42)29(41)28(40)25(15-37)49-32)24(45-3)13-27(47-18)48-20-4-9-34(17-38)22-5-8-33(2)21(19-12-26(39)46-16-19)7-11-36(33,44)23(22)6-10-35(34,43)14-20/h12,17-18,20-25,27-32,37,40-44H,4-11,13-16H2,1-3H3/t18-,20?,21?,22?,23?,24+,25+,27+,28+,29-,30+,31?,32-,33?,34?,35?,36-/m1/s1

Related news

Calcium uptake in mitochondria and vesicles of heart and skeletal muscle in presence of potassium, sodium, K-STROPHANTHIN (cas 11005-63-3) and pentobarbital☆08/23/2019

45Ca++ uptake in mitochondria and vesicles of heart and skeletal muscle was measured in the presence of a low concentration of calcium. The following results were obtained. (1) In mitochondria there was a rapid and brief Ca++ uptake if succinate was present; when ATP was added, Ca++ uptake was s...detailed

Direct actions of K-STROPHANTHIN (cas 11005-63-3) on cellular metabolism of the kidney and their consequences for the formation of urine08/21/2019

k-Strophanthin, directly acting upon the kidneys, produces a modus of urine formation capable of eliminating large amounts of fluid (edema). It is the metabolism of tubular epithelium, determining the degree of blood flow in certain capillary areas of the kidneys, that mediates such a strophanth...detailed

Hemodynamic pattern following K-STROPHANTHIN (cas 11005-63-3) in normal and coronary artery disease patients08/15/2019

Hemodynamic effects of K-strophanthin (0.005 mg/kg i.v.) were evaluated in 7 normal and in 13 non-failing coronary artery disease patients (CAD). Volumetric parameters were obtained by single plane left ventricular angiography. The indexes of “pump” function, the end-systolic pressure-volume r...detailed