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K-STROPHANTHIN, also known as strophanthin, is a cardiac glycoside derived from the seeds of the plant Strophanthus gratus. It is characterized by its ability to inhibit the sodium-potassium pump in heart muscle cells, which results in an increase in the force of contractions and improved heart efficiency. K-STROPHANTHIN is traditionally used in medicine for treating heart conditions such as heart failure and is under investigation for its potential anti-cancer properties. Due to its potency, K-STROPHANTHIN requires careful administration under the supervision of a healthcare professional to avoid toxic effects.

11005-63-3

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11005-63-3 Usage

Uses

Used in Cardiac Medicine:
K-STROPHANTHIN is used as a cardiac stimulant for treating heart conditions such as heart failure. Its application is based on its ability to enhance the force of heart muscle contractions, thereby improving the heart's efficiency in pumping blood.
Used in Pharmaceutical Research:
K-STROPHANTHIN is used as a subject of research for its potential anti-cancer properties. Studies are exploring how K-STROPHANTHIN may be utilized in the development of treatments for various types of cancer, leveraging its biological activities to target and inhibit cancer cell growth.
Used in Drug Formulation:
K-STROPHANTHIN is used as an active pharmaceutical ingredient in the formulation of medications aimed at managing heart failure. Its inclusion in these formulations is due to its proven efficacy in strengthening cardiac contractions, which is crucial for the treatment of this condition.

Check Digit Verification of cas no

The CAS Registry Mumber 11005-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,1,0,0 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 11005-63:
(7*1)+(6*1)+(5*0)+(4*0)+(3*5)+(2*6)+(1*3)=43
43 % 10 = 3
So 11005-63-3 is a valid CAS Registry Number.
InChI:InChI=1/C36H54O14/c1-18-31(50-32-30(42)29(41)28(40)25(15-37)49-32)24(45-3)13-27(47-18)48-20-4-9-34(17-38)22-5-8-33(2)21(19-12-26(39)46-16-19)7-11-36(33,44)23(22)6-10-35(34,43)14-20/h12,17-18,20-25,27-32,37,40-44H,4-11,13-16H2,1-3H3/t18-,20?,21?,22?,23?,24+,25+,27+,28+,29-,30+,31?,32-,33?,34?,35?,36-/m1/s1

11005-63-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name K-STROPHANTHIN

1.2 Other means of identification

Product number -
Other names kombe-strophanthin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:11005-63-3 SDS

11005-63-3Upstream product

11005-63-3Downstream Products

11005-63-3Related news

Calcium uptake in mitochondria and vesicles of heart and skeletal muscle in presence of potassium, sodium, K-STROPHANTHIN (cas 11005-63-3) and pentobarbital☆08/23/2019

45Ca++ uptake in mitochondria and vesicles of heart and skeletal muscle was measured in the presence of a low concentration of calcium. The following results were obtained. (1) In mitochondria there was a rapid and brief Ca++ uptake if succinate was present; when ATP was added, Ca++ uptake was s...detailed

Direct actions of K-STROPHANTHIN (cas 11005-63-3) on cellular metabolism of the kidney and their consequences for the formation of urine08/21/2019

k-Strophanthin, directly acting upon the kidneys, produces a modus of urine formation capable of eliminating large amounts of fluid (edema). It is the metabolism of tubular epithelium, determining the degree of blood flow in certain capillary areas of the kidneys, that mediates such a strophanth...detailed

Hemodynamic pattern following K-STROPHANTHIN (cas 11005-63-3) in normal and coronary artery disease patients08/15/2019

Hemodynamic effects of K-strophanthin (0.005 mg/kg i.v.) were evaluated in 7 normal and in 13 non-failing coronary artery disease patients (CAD). Volumetric parameters were obtained by single plane left ventricular angiography. The indexes of “pump” function, the end-systolic pressure-volume r...detailed

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