110087-30-4

Upstream product

• 115140-86-8 (E)-3-(6-Bromo-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-acrylonitrile 
• 110087-29-1 3-(6-Bromo-benzo[1,3]dioxol-5-yl)-2-cyano-3-(3,4,5-trimethoxy-phenyl)-propionic acid methyl ester 
• 296262-51-6 (E)-3-(6-Bromo-benzo[1,3]dioxol-5-yl)-2-cyano-acrylic acid methyl ester 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 2675-79-8 1-bromo-3,4,5-trimethoxybenzene 
• 115118-06-4 3-(6-Bromo-benzo[1,3]dioxol-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionitrile 
• 94670-94-7 6-bromobenzo-1,3-dioxol-5-yl 3,4,5-trimethoxyphenyl ketone 
• 869547-74-0 3-(6-Bromo-benzo[1,3]dioxol-5-yl)-2-cyano-3-(3,4,5-trimethoxy-phenyl)-propionic acid 

Downstream Products

• 107377-30-0 3-(6-Bromo-benzo[1,3]dioxol-5-yl)-3-(3,4,5-trimethoxy-phenyl)-propionic acid ethyl ester 
• 110087-31-5 (1R,2S)-2-(3,4,5-Trimethoxy-phenyl)-1,2-dihydro-4,6-dioxa-cyclobuta[f]indene-1-carbonitrile 
• 104715-47-1 (4aS,5S,6S,11bS)-2-Oxo-6-(3,4,5-trimethoxy-phenyl)-3,4,4a,5,6,11b-hexahydro-2H-1,8,10-trioxa-3-aza-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 104759-83-3 (4aR,5R,6S,11bS)-2-Oxo-6-(3,4,5-trimethoxy-phenyl)-3,4,4a,5,6,11b-hexahydro-2H-1,8,10-trioxa-3-aza-cyclopenta[b]phenanthrene-5-carboxylic acid methyl ester 
• 104715-44-8 (E)-4-[(1R,2S)-2-(3,4,5-Trimethoxy-phenyl)-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino]-but-2-enoic acid methyl ester 
• 104715-45-9 (E)-4-[(1R,2S)-2-(3,4,5-Trimethoxy-phenyl)-1,2-dihydro-4,6-dioxa-cyclobuta[f]inden-1-yloxycarbonylamino]-but-2-enoic acid 
• 107377-32-2 2-(3,4,5-Trimethoxy-phenyl)-1,2-dihydro-4,6-dioxa-cyclobuta[f]indene-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

A Highly Stereoselective Synthesis of Podophyllotoxin and Analogues Based on an Intramolecular Diels-Alder Reaction

A synthesis of podophyllotoxin and several analogues is described.The key step that generates all four chiral centers of podophylotoxin involves an intramolecular Diels-Alder reaction between an appropriately substituted o-quinodimethane and a pendant cro

A DIRECT SYNTHESIS OF TRANS 2-ARYLBENZOCYCLOBUTENOL, A POTENTIAL INTERMEDIATE FOR PODOPHYLLOTOXIN SYNTHESIS: USE OF LDA FOR BENZYNE FORMATION AND TRAPPING

Treatment of m-alkoxyaryl bromides with LDA in THF produces the corresponding aryne which can be trapped intramolecularly by an anion α to a nitrile to produce a substituted benzocyclobutenyl nitrile, the precursor of a trans arylbenzocyclobutenol potenti