110100-05-5

Upstream product

• 122476-85-1 2-methylsulphonyl-5-tributylstannylpyrimidine 
• 98-88-4 benzoyl chloride 
• 110099-94-0 2-(methylsulfanyl)-5-pyrimidinecarboxylic acid 
• 111252-99-4 5-benzoyl-2-methylthiopyrimidine-4-carboxylic acid 
• 73781-88-1 ethyl 2-(methylthio)pyrimidine-5-carboxylate 
• 110099-95-1 2-(methylthio)pyrimidine-5-carbonyl chloride 
• 50593-92-5 5-bromo-2-methylsulfanyl-pyrimidine-4-carboxylic acid 
• 122476-80-6 2-methylsulphonyl-5-trimethylstannylpyrimidine 
• 110099-97-3 5-benzoyl-2-methylthiopyrimidine 

Downstream Products

• 111275-96-8 5-benzoyl-1-benzyl-2(1H)-pyrimidinone 
• 110100-04-4 5-benzoyl-2-(1H)-pyrimidinone 

Relevant academic research and scientific papers

Synthesis of 5-Stannylpyrimidines and their Use in Pd-Catalysed Ketone Formation

2-(Dimethyl-t-butylsiloxy)-5-stannylpyrimidines have been prepared from the lithiated pyrimidine precursor. 2-Methylthio-5-stannylpyrimidines were prepared similarly and oxidized chemoselectively to the corresponding sulphones. 5-Stannylpyrimidin-2(1H)-ones can be prepared by fluoride-induced removal of the silyl group in 2-(dimethyl-t-butylsiloxy)-5-stannylpyrimidines, and the 5-stannylated pyrimidinones can be N-alkylated.The stannylated pyrimidines are stable compounds which react readily with acid chlorides in Pd-catalysed reaction with formation of 5-pyrimidinyl ketones.

Organomanganese(II) Reagents in the Synthesis of 5-Pyrimidinyl Ketones

Substituted alkyl 5-pyrimidinyl ketones were formed from acid chlorides of pyrimidine-5-carboxylic acids and alkylmanganese(II) iodides.The corresponding alcohols were also formed in the case of sterically less requiring organomanganese reagents and the a

Lithiation in the Synthesis of 5-Pyrimidinyl Ketones

A method for the preparation of 2-substituted 5-pyrimidinyl aryl or heteroaryl ketones from 5-bromo-2-methylthiopyrimidine-4-carboxylic acid is described.The latter was lithiated and reacted with an aroyl or heteroaroyl chloride to give the corresponding