1101146-34-2

Upstream product

• 1101147-31-2 tert-butyl {2-[2-(1,3-dihydroisoindol-2-yl)-2-oxoacetyl]-4-iodophenyl}carbamate 
• 1228311-56-5 tert-butyl 5-iodo-2,3-dioxo-2,3-dihydroindole-1-carboxylate 
• 20780-76-1 5-iodoisatin 
• 1101145-49-6 (2-amino-6-iodoquinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone 
• 40138-16-7 2-formylbenzene boronic acid 

Downstream Products

• 1101146-67-1 {2-amino-6-[2-(4-methylpiperazin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1101146-50-2 2-amino-6-(2-piperazin-1-ylmethylphenyl)-4-(1,3-dihydro-isoindol-2-ylcarbonyl)quinazoline 
• 1367454-63-4 methyl 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-benzyl}pyrrolidine-2-carboxylate 
• 1367454-67-8 {2-amino-6-[2-(4-hydroxypiperidin-1-ylmethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-64-5 1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}-pyrrolidine-2-carboxylic acid 
• 1367454-65-6 N-methyl-1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-benzyl}pyrrolidine-2-carboxamide 
• 1367454-66-7 N-(2-hydroxyethyl)-1-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzyl}pyrrolidine-2-carboxamide 
• 1367454-36-1 (2-amino-6-{2-[(ethylmethylamino)methyl]phenyl}quinazolin-4-yl)-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-38-3 [2-amino-6-(2-diethylaminomethylphenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-39-4 [2-amino-6-(2-{[(2-hydroxyethyl)methylamino]methyl}phenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-40-7 [2-amino-6-(2-{[(2-hydroxyethyl)ethylamino]methyl}phenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-43-0 [2-amino-6-(2-{[bis-(2-hydroxyethyl)amino]methyl}phenyl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-44-1 {2-amino-6-[2-(tert-butylaminomethyl)phenyl]quinazolin-4-yl}-(1,3-dihydroisoindol-2-yl)methanone 
• 1367454-48-5 2-{2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]benzylamino}acetamide 

Relevant academic research and scientific papers

PHENYLQUINAZOLINE DERIVATIVES

Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Quinazolinamide derivatives

Novel quinazolinamide derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.