110144-22-4Relevant articles and documents
Ring-in-ring(s) complexes exhibiting tunable multicolor photoluminescence
Wu, Huang,Wang, Yu,Jones, Leighton O.,Liu, Wenqi,Song, Bo,Cui, Yunpeng,Cai, Kang,Zhang, Long,Shen, Dengke,Chen, Xiao-Yang,Jiao, Yang,Stern, Charlotte L.,Li, Xiaopeng,Schatz, George C.,Fraser Stoddart
, p. 16849 - 16860 (2020)
One ring threaded by two other rings to form a non-intertwined ternary ring-in-rings motif is a challenging task in noncovalent synthesis. Constructing multicolor photoluminescence systems with tunable properties is also a fundamental research goal, which
Metal-Metal Interactions Across Symmetrical Bipyridyl Bridging Ligands in Binuclear Seventeen-electron Molybdenum Complexes
Das, Amitava,Maher, John P.,McCleverty, Jon A.,Badiola, Jon A. Navas,Ward, Michael D.
, p. 681 - 686 (1993)
A series of 17-electron mononuclear complexes and their binuclear counterparts 2(μ-X)> benzene (bpeb) or 1,4-bis(4-pyridyl)benzene (bpb)> have been prepared.Electrochemical studies show that the reduction potentials of the mononuclear complexes are sensitive to the degree of unsaturation in the monodentate ligand X, whereas the oxidation potentials are virtually constant.This suggests that the redox orbital involved in the reductions have considerable ligand-based character whereas the oxidations are more strongly metal-centred.This is supported by the electrochemical properties of the binuclear complexes, where the oxidation potentials are in every case coincident but the splitting between the reduction potentials of the equivalent molybdenum centres varies from 0.16 V (X = bpeb) to 0.56 V (X = bpac).By contrast the splitting of the redox potentials of pentaammineruthenium(II) fragments at either end of 'extended' 4,4'-bipyridine analogues of this type is an order of magnitude smaller.This strong interaction between moieties is in part due to a planar conformation of the bridging ligands, even when they are in principle capable of free rotation, since changing the bridging ligand from 4,4'-bipyridine to 3,3'-dmbipy (which cannot be planar due to the steric effects of the methyl groups) results in a decrease in the splitting of the reduction potentials from 0.77 to 0.38 V.The EPR spectra of the binuclear complexes all show that the two unpaired electrons (one at each 17-electron molybdenum centre) are in fast exchange across the bridging ligand at room temperature.
Acidochromism of C2-symmetrical aza-analogues of 1,4-distyrylbenzene
Detert, Heiner,Sadovski, Oleg,Sugiono, Erli
, p. 1046 - 1050 (2004)
A series of C2-symmetrical aza-analogous 1,4-distyrylbenzenes were synthesised via two-fold PO-activated olefinations or Heck reactions. Pyridine, pyrimidine and quinoline were used as terminal rings, and the 2,5-positions of the central benzen
Solvent-Mediated Synthesis of Cyclobutane Isomers in a Photoactive Cadmium(II) Porous Coordination Polymer
Claassens, Isabella E.,Nikolayenko, Varvara I.,Haynes, Delia A.,Barbour, Leonard J.
, p. 15563 - 15566 (2018)
Photochemical [2+2] cycloaddition of 1,4-bis[2-(4-pyridyl)ethenyl]benzene, carried out in a CdII porous coordination polymer (PCP), produces different isomeric products depending on the guest solvent present in the PCP during irradiation. The n
Immobilized Pd on a NHC-functionalized metal-organic FrameworkMIL-101(Cr): An efficient heterogeneous catalyst in the heck and copper-free Sonogashira coupling reactions
Niknam, Esmaeil,Panahi, Farhad,Khalafi-Nezhad, Ali
supporting information, (2021/01/12)
A heterogeneous palladium catalyst system based on immobilization of palladium moieties on a N-heterocyclic carbene (NHC) modified metal organic framework (MOF) was developed for the Heck and copper-free Sonogashira coupling reactions. In order to prepare this catalyst system, first, MIL-101(Cr) was functionalized with NHC moieties through a post synthetic modification (PSM) approach, and then Pd metal was stabilized on the prepered MIL-101(Cr)-NHC substrate. This material was characterized using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphology and structure of MIL-101(Cr) template during the reaction progress. Also, existence of palladium nanoparticles immobilized on the MOF structure affirmed by the TEM and XPS analysis confirmed the oxidation state of Pd. A variety of alkene and alkyne derivatives were synthesized in good to excellent yields using this heterogeneous Pd catalyst system under normal conditions. More importantly Pd-NHC-MIL-101(Cr) catalyst was simply recovered from the reaction medium without remarkable decreasing in its catalytic activities after five times of reusability. The ICP analysis showed the very low Pd and Cr metals leaching, representing high stability and applicability of this catalyst in Pd coupling reactions.
A pyridine chain conjugated system polymer derivatives and its preparation method and application (by machine translation)
-
Paragraph 0181-0186, (2019/06/07)
The invention discloses a pyridine chain conjugated system polymer derivatives and its preparation method and application, relates to the field of organic synthetic technology. The compounds of the invention have the general formula 1, formula 2, formula 3 or formula 4 four kinds of structure; wherein R1 To bromine, methyl, tert-butyl, methoxy, ester or amide group; m is 2 or 3; formula 2 R in the2 Bromo, ester group, amido group or a carboxyl group; R3 Is hydrogen, fluoro, methyl, methoxy, ester or amide; formula 3 or formula 4 in the X is a carbon atom or a nitrogen atom; R4 Hydrogen, methyl, fluorine, chlorine, bromine or nitro; Y is a carbon atom or a nitrogen atom; Z is imino or oxygen atom. The invention synthetic compounds of rotenone induced PC12 cell injury has obvious protection functions, and to α - Syn protein aggregation and fibrosis has obvious inhibition, statistical significance, may be further developed to be used for the treatment of Parkinson's drug; the general formula 1 - general formula 4 are respectively: (by machine translation)
Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation
Liu, Hao,Chen, Li,Zhou, Fei,Zhang, Yun-Xiao,Xu, Ji,Xu, Meng,Bai, Su-Ping
supporting information, p. 3089 - 3096 (2019/06/14)
Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.
Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds
Nabuurs, Rob J.A.,Kapoerchan, Varsha V.,Metaxas, Athanasios,Hafith, Sarah,de Backer, Maaike,Welling, Mick M.,Jiskoot, Wim,van den Nieuwendijk, Adrianus M.C.H.,Windhorst, Albert D.,Overkleeft, Herman S.,van Buchem, Mark A.,Overhand, Mark,van der Weerd, Louise
, p. 6139 - 6148 (2016/11/30)
Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. However, these compounds are relatively hydrophobic, which likely limits their in vivo potential. Based on their structures, we hypothesized that less hydrophobic bis-pyridylethenylbenzenes may also label amyloid. We synthesized several bis-pyridylethenylbenzenes and tested whether these compounds indeed display improved solubility and lower Log?P values, and studied their fluorescent properties and Aβ binding characteristics. Bis-pyridylethenylbenzenes showed a clear affinity for Aβ plaques on both human and murine AD brain sections. Competitive binding experiments suggested a different binding site than Chrysamine G, a well-known stain for amyloid. With a Log?P value between 3 and 5, most bis-pyridylethenylbenzenes were able to enter the brain and label murine amyloid in vivo with the bis(4-pyridylethenyl)benzenes showing the most favorable characteristics. In conclusion, the presented results suggest that bis-pyridylethenylbenzene may serve as a novel backbone for amyloid imaging agents.
Controlled formation of chiral networks and their reversible chiroptical switching behaviour by UV/microwave irradiation
Hu, Fei-Long,Wang, Hui-Fang,Guo, Dong,Zhang, Hui,Lang, Jian-Ping,Beves, Jonathon E.
supporting information, p. 7990 - 7993 (2016/07/06)
A 3D coordination polymer {[Cd(L1)(L2)]2}n (1) spontaneously resolves into enantiomorphic crystals of 1P and 1M without any chiral source. Bulk quantities of 1P and 1M can be predictably and reliably obtained by
Synthesis, optical, and thermal properties of conjugated, bispyridyl and tetrapyridyl compounds by Knoevenagel reaction
Bhowmik, Pradip K.,Nedeltchev, Alexi K.,Han, Haesook
, p. 5383 - 5387 (2008/02/10)
A series of conjugated, bispyridyl and tetrapyridyl compounds were synthesized from either terephthalaldehyde or isophthalaldehyde and activated pyridyl compounds by Knoevenagel reaction on heating in acetic anhydride in presence of acetic acid and their
