110177-67-8Relevant academic research and scientific papers
Benzyl chloroformate (CbzCl) synthesis using carbon monoxide as a carbonyl source
Mizuno, Takumi,Takahashi, Junko,Ogawa, Akiya
, p. 10011 - 10015 (2002)
A novel non-phosgene synthetic method for benzyl chloroformate (CbzCl) was established. S-Methyl O-benzyl carbonothioates were prepared by the carbonylation of benzyl alcohols with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide in good yields. Then, CbzCl derivatives were successfully synthesized by the chlorination of S-methyl O-benzyl carbonothioates using sulfuryl chloride in excellent yields.
Non-phosgene synthesis of benzyl chloroformate (CbzCl)
Mizuno, Takumi,Takahashi, Junko,Ogawa, Akiya
, p. 7765 - 7767 (2007/10/03)
A novel synthetic method for benzyl chloroformate (CbzCl) using carbon monoxide or carbonyl sulfide as a carbonyl source was established. Benzyl chloroformate was successfully synthesized by the chlorination using sulfuryl chloride of S-methyl O-benzyl carbonothioate, which was prepared by the carbonylation of benzyl alcohol with carbon monoxide and sulfur (or carbonyl sulfide) in the presence of DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) followed by esterification using methyl iodide.
