110179-96-9

Basic information

• Product Name: 2-methyl-N-(4-nitrophenyl)benzamide
• Synonyms: 2-Methyl-N-(4-nitrophenyl)benzamide; benzamide, 2-methyl-N-(4-nitrophenyl)-
• CAS NO: 110179-96-9
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.2567
• Mol File: 110179-96-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 352.6°C at 760 mmHg
• Flash Point: 167.1°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 3.79E-05mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 2-methyl-N-(4-nitrophenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-(4-nitrophenyl)benzamide(110179-96-9)
• EPA Substance Registry System: 2-methyl-N-(4-nitrophenyl)benzamide(110179-96-9)

Safety Data

• Hazardous Substances Data: 110179-96-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12N2O3/c1-10-4-2-3-5-13(10)14(17)15-11-6-8-12(9-7-11)16(18)19/h2-9H,1H3,(H,15,17)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 100-01-6 4-nitro-aniline 
• 933-88-0 ortho-toluoyl chloride 
• 62-53-3 aniline 
• 7055-03-0 2-methyl-N-phenylbenzamide 
• 95-49-8 2-methylchlorobenzene 

Relevant articles and documents

Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments

VEGF/VEGFR-2 signaling plays a critical part in tumor angiogenesis. Inhibition of this pathway has been considered as a promising approach for cancer treatment. In this work, a series of 6,7-dimethoxy-4-anilinoquinazoline derivatives bearing diarylamide moiety were designed, synthesized and evaluated as potent inhibitors of VEGFR-2 kinase. Their in vitro antiproliferation activities against two human cancer cell lines Hep-G2 and MCF-7 have also been determined. Among them, compound 14b exhibited the most potent inhibitory activity against VEGFR-2 with IC50 value of 0.016 ± 0.002 μM and it showed the most potent antiproliferative effect against Hep-G2 and MCF-7 with IC50 values at low-micromolar range. Molecular docking studies revealed that these compounds represented by the most potent compound 14b could bind well to the ATP-binding site of VEGFR-2, which suggested that compound 14b could be a potential anticancer agent targeting VEGFR-2.