110189-03-2

Upstream product

• 876945-78-7 3-(4-(benzyloxy)phenyl)-2-((tert-butoxycarbonyl)(methyl)amino)propanoic acid 
• 2990-25-2 tyrozine hydrochloride 
• 142847-18-5 N-(tert-butoxycarbonyl)tyrosine 
• 3978-80-1 Boc-Tyr-OH 
• 60-18-4 L-tyrosine 
• 64263-81-6 N-(tert-butyloxycarbonyl)-N-methyl-O-(phenylmethyl)-L-tyrosine 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 40167-10-0 2-[4-(benzyloxy)phenyl]acetaldehyde 
• 1262680-30-7 1-(4-(benzyloxy)phenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine 
• 1262680-53-4 N-allyl-1-(4-(benzyloxy)phenyl)-4-(4-methoxyphenyl)-N-methylbut-3-yn-2-amine 
• 1370367-09-1 C₂₁H₂₃NO₂ 
• 7339-87-9 4-hydroxyphenylacetaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 1262680-64-7 (2E,5Z)-tert-butyl 4-(4-(benzyloxy)benzyl)-2-(tert-butoxycarbonylimino)-5-(4-methoxybenzylidene)-3-methylimidazolidine-1-carboxylate 

Downstream Products

• 110189-06-5 naamidine A 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

Naamines and naamidines as novel agents against a plant virus and phytopathogenic fungi

Naamines, naamidines and various derivatives of these marine natural products were synthesized and characterized by means of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The activities of these alkaloids against a plant virus and phytopathogenic fungi were evaluated for the first time. A benzyloxy naamine derivative 15d displayed excellent in vivo activity against tobacco mosaic virus at 500 μg/mL (inactivation activity, 46%; curative activity, 49%; and protective activity, 41%); its activities were higher than the corresponding activities of the commercial plant virucide ribavirin (32%, 35%, and 34%, respectively), making it a promising new lead compound for antiviral research. In vitro assays revealed that the test compounds exhibited very good antifungal activity against 14 kinds of phytopathogenic fungi. Again, the benzyloxy naamine derivative 15d exhibited broad-spectrum fungicidal activity, emerging as a new lead compound for fungicidal research. Additional in vivo assays indicated that many of the compounds displayed inhibitory effects >30%.

Naamine derivatives, preparation method of Nammine derivatives, and application of Nammine derivatives in treatment of plant viruses and bacterial diseases

The invention discloses Naamine derivatives, a preparation method of the Nammine derivatives, and an application of the Nammine derivatives in treatment of plant viruses and bacterial diseases. The Nammine derivatives specifically are compounds represented as formulae from I-1 to I-16. During each reaction, materials participating in the reaction are taken according to the molar ratio required bythe reaction; excess substances are selected to participate in the reaction so as to ensure the reaction process of a target product; the pH value and reacting temperature and time of a system are determined according to the reaction type; and purifying separation or drying is carried out after the preparation. The Naamine derivatives provided by the invention exhibit good activity for treating plant viruses and bacterial diseases, and can well inhibit the following 14 species of plant pathogenic bacteria: tobacco mosaic virus (TMV), Fusarium oxysporum (Schl.)F.sp cucumerinum Owen, cercosporaarachidicola, Botryospuaeria berengeriana, Rhizotonia cerealis van der Hoeven apud.Boerema & Verhoeven, Helminthosporium maydis Nisik & Miy, Colleetotrichum lagenarium (Pass.) Ell. et Halst, fusariummoniliforme, Alternaria solani, FusaHum graminearum, Phytophthora infestans, phytophthora capsici, sclerotinia sclerotiorum, Botrytis cinerea and Thanatephorus cucumeris.

Synthesis of Naamidine A and Selective Access to N2-Acyl-2-aminoimidazole Analogues

A short and scalable synthesis of naamidine A, a marine alkaloid with a selective ability to inhibit epidermal growth factor receptor (EGFR)-dependent cellular proliferation, has been achieved. A key achievement in this synthesis was the development of a

COMPOSITIONS AND METHODS COMPRISING 2-(ACYLAMINO)IMIDAZOLES

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

POLYSUBSTITUTED 2-AMINOIMIDAZOLES FOR CONTROLLING BIOFILMS AND PROCESS FOR THEIR PRODUCTION

The present invention relates to compounds, compositions and methods for controlling and/or preventing biofilms and bacterial infections, being polysubstituted 2-amino-imidazoles with the structural formula (I). wherein R1 is H, an aliphatic gr

Concise and diversity-oriented route toward polysubstituted 2-aminoimidazole alkaloids and their analogues

Alkaloids of the naamine family were synthesized from diverse propargylamines in just two steps (see scheme: R1=Me, R 2=substituted benzyl, R3=Ar). Thus, the addition to a propargylamine of a carbodiimide generated in situ

A concise total synthesis of naamidine A

A total synthesis of naamidine A is reported. Key benefits of the described pathway include its brevity, its synthetic ease, and its flexibility with respect to the preparation of analogues. Formation of the 2-aminoimidazole core is achieved by condensati

Total syntheses of naamine A and naamidine A, marine imidazole alkaloids

The first total syntheses of naamine A (4) and naamidine A (5), marine imidazole alkaloids, were achieved through twelve and thirteen steps of reactions, respectively, starting from 1-methyl-2-phenylthio-1H-imidazole (17).