110211-35-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1823-14-9 5-phenyl-1-pentyne 
• 110211-31-9 Acetic acid 1-phenethyl-3-trimethylsilanyl-prop-2-ynyl ester 
• 35761-91-2 5-iodo-1-trimethylsilyl-1-pentyne 
• 996-50-9 N,N-diethyl-1,1,1-trimethylsilanamine 
• 1078-58-6 diphenylzinc 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 
• 637-59-2 1-Bromo-3-phenylpropane 
• 54655-07-1 lithium trimethylsilylacetylenide 
• 104-53-0 3-phenyl-propionaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 60-12-8 2-phenylethanol 
• 122-97-4 3-Phenyl-1-propanol 
• 66950-73-0 3-phenylpropyl 1-trifluoromethanesulfonate 

Downstream Products

• 136859-79-5 5-phenyl-1-phenylselenopent-1-yne 
• 121572-26-7 phenyl (5-phenylpent-1-ynyl) sulfide 
• 136859-84-2 C₂₉H₂₆Se₃ 
• 135939-54-7 (Z)-trimethyl(5-phenylpent-1-en-1-yl)silane 
• 1554260-58-0 (9-(4-chlorophenyl)-6,7-dihydro-5H-benzo[7]annulen-8-yl)-diphenylphosphine oxide 
• 1554260-59-1 (E)-(1-(4-chlorophenyl)-5-phenylpent-1-en-2-yl)-diphenylphosphine oxide 
• 1554260-80-8 C₂₉H₂₆ClOP 
• 1554260-28-4 1-chloro-4-(5-phenylpent-1-yn-1-yl)benzene 
• 1823-14-9 5-phenyl-1-pentyne 

Relevant academic research and scientific papers

Nickel-catalyzed cross-coupling of primary alkyl halides with phenylethynyl- and trimethylsilyethynyllithium reagents

A highly efficient alkyl-alkynyl coupling system is described which is promoted by a well-defined and moisture-stable pincer complex [NiCl{C 6H3-2,6-(OPPh2)2}] (1). Non-activated alkyl halides could be efficient

DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC)

This present disclosure relates to protein kinase C (PKC) modulating compounds, methods of treating a subject with cancer using the compounds, and combination treatments with a second therapeutic agent.

Titanium-Promoted Cross-Coupling for the Selective Synthesis of Polysubstituted, Conjugated Amides

α,β-Unsaturated amides are important building blocks and are key structural elements in a number of biologically active natural products. Despite their importance and prevalence, few methods exist to prepare conjugated amides directly and modularly. To address this gap, a titanium-promoted coupling of alkynes and isocyanates has been developed. The method is highly stereoselective, producing only the E isomer with good chemoselectivity and regioselectivity (>95/5), for unsymmetrical internal alkynes that contain a steric bias. The reactive titanacyclopentene intermediate formed from the coupling of the alkyne and isocyanate was additionally reacted with various electrophiles to access tetrasubstituted enamides.

Enantioselective synthesis of α-aminosilanes by copper-catalyzed hydroamination of vinylsilanes

The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric reductant, and O-benzoylhyd

Manganese(III)-mediated selective diphenylphosphinoyl radical reaction of 1,4-diaryl-1-butynes for the synthesis of 2-phosphinoylated 3,4- dihydronaphathalenes

A diphenylphosphinoyl radical-initiated sequential reaction of 1,4-diaryl-1-butynes and analogues is developed for the synthesis of 2-phosphinoylated 3,4-dihydronaphathalenes and related compounds.

C(sp)-C(sp3) bond formation through cu-catalyzed cross-coupling of N -tosylhydrazones and trialkylsilylethynes

Copper-catalyzed cross-coupling of N-tosylhydrazones with trialkylsilylethynes leads to the formation of C(sp)-C(sp3) bonds. Cu carbene migratory insertion is proposed to play the key role in this transformation.

Zinc-catalyzed silylation of terminal alkynes

(Chemical Equation Presented) A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and catalytic quantities of Zn(OTf) 2 has been developed. The reaction works well for a variety of substrates including reactive esters. Fifteen examples with yields of >90% are reported.

Exploring skeletal diversity via ring contraction of glycal-derived scaffolds

(Chemical Equation Presented) Aryl ether C-glycoside scaffolds have been prepared from tri-O-acetyl-D-glucal by C-glycosylation followed by allylic substitution with phenols mediated by Pd(0). The aryl ethers were subjected to either [3,3]-sigmatropic rea

PROCESS FOR PRODUCTION OF AROMATIC COMPOUNDS

A problem of the present invention is to provide an economical process with minimized toxicity for producing an aromatic compound having a variety of substituents such as various alkyl groups, and the problem is solved by a process for production of an aromatic compound represented by formula (1) below, which comprises reacting a compound represented by formula (2) below with an aromatic magnesium reagent represented by formula (3a) below in the presence of an iron catalyst and a diamine compound: wherein R is an optionally substituted hydrocarbon group or a C 3 - C 10 saturated or unsaturated ring group; A is an optionally substituted C 4 - C 20 aromatic group or an optionally substituted heteroaromatic group; X is a halogen atom or a sulfonic acid ester; and Y 1 is bromine, iodine, chlorine or a carbanion ligand.

Iron-catalyzed chemoselective cross-coupling of primary and secondary alkyl halides with arylzinc reagents

Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction. Georg Thieme Verlag Stuttgart.