110236-60-7

Basic information

• Product Name: Methyl-4-O-(2-O-acetyl-3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid
• CAS NO: 110236-60-7
• Molecular Weight: 841.953
• Mol File: 110236-60-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Methyl-4-O-(2-O-acetyl-3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-4-O-(2-O-acetyl-3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid(110236-60-7)
• EPA Substance Registry System: Methyl-4-O-(2-O-acetyl-3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid(110236-60-7)

Safety Data

• Hazardous Substances Data: 110236-60-7(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 108-24-7 acetic anhydride 
• 110236-59-4 Methyl-3,6-di-O-benzyl-4-O-(3-O-benzyl-4,6-O-isopropyliden-α-L-idopyranosyl)-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 60076-41-7 methyl 4,6-O-benzylidene-2-(benzyloxycarbonyl)-amino-2-deoxy-α-D-glucopyranoside 
• 87907-34-4 ((2S,4aR,6S,7R,8R,8aS)-8-Benzyloxy-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-carbamic acid benzyl ester 
• 100-39-0 benzyl bromide 
• 4704-15-8 ((2S,3R,4R,5S,6R)-4,5-Dihydroxy-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3-yl)-carbamic acid benzyl ester 
• 60076-41-7 methyl 4,6-O-benzylidene-2-(benzyloxycarbonyl)amino-2-deoxy-α-D-glucopyranoside 
• 87907-34-4 methyl 3-O-benzyl-4,6-O-benzylidene-2-(benzyloxycarbonyl)amino-2-deoxy-α-D-glucopyranoside 
• 110236-57-2 Acetic acid (2S,3R,4S,5R,6S)-5-acetoxy-6-acetoxymethyl-4-benzyloxy-2-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-3-yl ester 
• 110236-58-3 Methyl-3,6-di-O-benzyl-4-O-(3-O-benzyl-α-L-idopyranosyl)-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 110236-56-1 methyl N-benzyloxycarbonyl-2-deoxy-3,6-di-O-benzylglucopyranoside 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 3006-58-4 2-carbobenzyloxyamino-2-deoxy-D-glucopyranose 

Downstream Products

• 110255-42-0 (2R,3S,4S,5R,6R)-5-Acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-3-hydroxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 256348-58-0 5-acetoxy-3-(6-acetoxymethyl-3-azido-4-benzyloxy-5-methoxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-(4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 110236-63-0 4-Oxo-pentanoic acid (2S,3R,4S,5R,6S)-5-acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-pyran-3-yl ester 
• 110236-62-9 Acetic acid (2S,3R,4S,5R,6S)-4-benzyloxy-2-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-hydroxy-tetrahydro-pyran-3-yl ester 
• 110236-66-3 (2R,3S,4S,5R,6R)-5-Acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 110236-65-2 (2R,3S,4S,5R,6R)-5-Acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-3-(4-oxo-pentanoyloxy)-tetrahydro-pyran-2-carboxylic acid 
• 110236-64-1 4-Oxo-pentanoic acid (2S,3R,4S,5R,6S)-5-acetoxy-4-benzyloxy-6-((2R,3S,4R,5R,6S)-4-benzyloxy-5-benzyloxycarbonylamino-2-benzyloxymethyl-6-methoxy-tetrahydro-pyran-3-yloxy)-2-hydroxymethyl-tetrahydro-pyran-3-yl ester 
• 112622-69-2 C₆₈H₇₄N₄O₂₀ 
• 112622-71-6 C₆₂H₇₀N₄O₁₆ 
• 112622-67-0 Methyl-4-O-(2-O-acetyl-6-O-benzoyl-3-O-benzyl-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 112622-70-5 Methyl-O-(6-O-acetyl-2-azido-3,4-di-O-benzyl-2-desoxy-α-D-glucopyranosyl)-(1->4)-O-(2-O-acetyl-6-O-benzoyl-3-O-benzyl-α-L-idopyranosyl)-(1->4)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 
• 110236-61-8 Methyl-4-O-(2-O-acetyl-3-O-benzyl-α-L-idopyranosyl)-3,6-di-O-benzyl-2-(benzyloxycarbonylamino)-2-desoxy-α-D-glucopyranosid 

Relevant articles and documents

Synthesis of heparin partial structures and their binding activities to platelets

A synthetic pentasaccharide corresponding to the antithrombin III-binding region in heparin was also found to bind to human platelets. To identify the platelet-binding site in the pentasaccharide which is expected to be a novel sequence in heparin responsible for its platelet-binding, five partial structures of this particular pentasaccharide were synthesized. In a competitive assay using [3H]-heparin, a trisaccharide, O-(2-deoxy-2-sulfamido-3,6-di-O-sulfo-α-D-glucopyranosyl)- (1→4)-O-(2-O-sulfo-α-L-idopyranosyluronic acid)-(1→4)-2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranose, was concluded to be a high-affinity site for heparin's binding to platelets.

SYNTHESIS OF AN ANTITHROMBIN BINDING HEPARIN-LIKE PENTASACCHARIDE LACKING 6-O SULPHATE AT ITS REDUCING END.

The synthesis of a pentasaccharide of the structure of the antithrombin (AT-III) binding sequence, but lacking the 6-O sulphate group at the reducing end, is described and its α-Xa activity determined.